ID   T37i
AC   CVCL_S893
DR   EFO; EFO_0022805
DR   Millipore; SCC250
DR   Wikidata; Q54971528
RX   PubMed=9502766;
RX   PubMed=12482590;
CC   Characteristics: Can differentiate into brown adipocytes when incubated with triiodothyronine (T3) and insulin over 3-6 days. Differentiation can also be induced by incubation with steroid hormones such as aldosterone, which induces differentiation through its interaction with mineralocorticoid receptor (MR) (Millipore=SCC250).
CC   Genetic integration: Method=Transgenic mouse; Gene=UniProtKB; P03070; SV40 large T antigen.
CC   Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
CC   Derived from site: In situ; Brown adipose tissue; UBERON=UBERON_0001348.
CC   Breed/subspecies: C57BL/6 x DBA/2 SV40TAg transgenic.
ST   Source(s): Millipore=SCC250
ST   Mouse STR 1-1: 17
ST   Mouse STR 1-2: 18
ST   Mouse STR 2-1: 16
ST   Mouse STR 3-2: 14.2
ST   Mouse STR 4-2: 19.3,20.3
ST   Mouse STR 5-5: 13
ST   Mouse STR 6-4: 18
ST   Mouse STR 6-7: 12,16
ST   Mouse STR 7-1: 26.2
ST   Mouse STR 8-1: 16,17
ST   Mouse STR 11-2: 16,17
ST   Mouse STR 12-1: 16
ST   Mouse STR 13-1: 17
ST   Mouse STR 15-3: 22.3
ST   Mouse STR 17-2: 15
ST   Mouse STR 18-3: 16
ST   Mouse STR 19-2: 12,13
ST   Mouse STR X-1: 26
DI   NCIt; C21634; Mouse hibernoma
OX   NCBI_TaxID=10090; ! Mus musculus (Mouse)
SX   Female
AG   2W
CA   Transformed cell line
DT   Created: 03-02-14; Last updated: 10-04-25; Version: 13
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RX   PubMed=9502766; DOI=10.1172/JCI1915; PMCID=PMC508679;
RA   Zennaro M.-C., Le Menuet D., Viengchareun S., Walker F., Ricquier D.,
RA   Lombes M.;
RT   "Hibernoma development in transgenic mice identifies brown adipose
RT   tissue as a novel target of aldosterone action.";
RL   J. Clin. Invest. 101:1254-1260(1998).
//
RX   PubMed=12482590; DOI=10.1016/S0014-5793(02)03697-9;
RA   Viengchareun S., Zennaro M.-C., Pascual-Le Tallec L., Lombes M.;
RT   "Brown adipocytes are novel sites of expression and regulation of
RT   adiponectin and resistin.";
RL   FEBS Lett. 532:345-350(2002).
//