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Cellosaurus Ker-CT (CVCL_S877)

[Text version]
Cell line name Ker-CT
Accession CVCL_S877
Resource Identification Initiative To cite this cell line use: Ker-CT (RRID:CVCL_S877)
Comments Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
Genetic integration: Method=Transduction; Gene=MGI; MGI:88357; Cdk4.
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR).
Derived from site: In situ; Foreskin, skin, epidermis; UBERON=UBERON_0001471+UBERON_0001003.
Cell type: Keratinocyte; CL=CL_0000312.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_4T86 (Ker-CT-Ras)
Sex of cell Male
Age at sampling <1M
Category Telomerase immortalized cell line
STR profile Source(s): ATCC=CRL-4048

Markers:
AmelogeninX,Y
CSF1PO7,11
D5S81812
D7S82010,11
D13S31711,13
D16S5399,11
TH016,9
TPOX8
vWA15,16

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Publications

PubMed=12545164; DOI=10.1038/sj.onc.1206046
Ruben D. Ramirez, Brittney-Shea Herbert, Melville B. Vaughan, Ying Zou, Kenia G. Gandia, Carmela P. Morales, Woodring Erik Wright, Jerry W. Shay;
Bypass of telomere-dependent replicative senescence (M1) upon overexpression of Cdk4 in normal human epithelial cells.
Oncogene 22:433-444(2003)

PubMed=19936293; DOI=10.1371/journal.pone.0007908; PMCID=PMC2774948
Melville B. Vaughan, Ruben D. Ramirez, Celine Marlin Andrews, Woodring Erik Wright, Jerry W. Shay;
H-ras expression in immortalized keratinocytes produces an invasive epithelium in cultured skin equivalents.
PLoS ONE 4:e7908.1-e7908.9(2009)

DOI=10.13140/RG.2.2.17700.88960
Aaron Briley, Brian A. Shapiro;
hTERT-immortalized and primary keratinocytes differentiate into epidermal structures in 3D organotypic culture.
(In technical document) ATCC application note 17; pp.1-4; ATCC; Manassas; USA (2016)

Cross-references
Cell line collections (Providers) ATCC; CRL-4048
Encyclopedic resources Wikidata; Q54899807
Proteomic databases PRIDE; PXD028647
Entry history
Entry creation03-Feb-2014
Last entry update14-Aug-2025
Version number15