ID   Ker-CT
AC   CVCL_S877
DR   ATCC; CRL-4048
DR   PRIDE; PXD028647
DR   Wikidata; Q54899807
RX   DOI=10.13140/RG.2.2.17700.88960;
RX   PubMed=12545164;
RX   PubMed=19936293;
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
CC   Genetic integration: Method=Transduction; Gene=MGI; MGI:88357; Cdk4.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; S.alboniger pac (PuroR).
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
CC   Derived from site: In situ; Foreskin, skin, epidermis; UBERON=UBERON_0001471+UBERON_0001003.
CC   Cell type: Keratinocyte; CL=CL_0000312.
ST   Source(s): ATCC=CRL-4048
ST   Amelogenin: X,Y
ST   CSF1PO: 7,11
ST   D13S317: 11,13
ST   D16S539: 9,11
ST   D5S818: 12
ST   D7S820: 10,11
ST   TH01: 6,9
ST   TPOX: 8
ST   vWA: 15,16
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   <1M
CA   Telomerase immortalized cell line
DT   Created: 03-02-14; Last updated: 19-12-24; Version: 14
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RX   DOI=10.13140/RG.2.2.17700.88960;
RA   Briley A., Shapiro B.A.;
RT   "hTERT-immortalized and primary keratinocytes differentiate into
RT   epidermal structures in 3D organotypic culture.";
RL   (In technical document) ATCC application note 17; pp.1-4; ATCC; Manassas; USA (2016).
//
RX   PubMed=12545164; DOI=10.1038/sj.onc.1206046;
RA   Ramirez R.D., Herbert B.-S., Vaughan M.B., Zou Y., Gandia K.G.,
RA   Morales C.P., Wright W.E., Shay J.W.;
RT   "Bypass of telomere-dependent replicative senescence (M1) upon
RT   overexpression of Cdk4 in normal human epithelial cells.";
RL   Oncogene 22:433-444(2003).
//
RX   PubMed=19936293; DOI=10.1371/journal.pone.0007908; PMCID=PMC2774948;
RA   Vaughan M.B., Ramirez R.D., Andrews C.M., Wright W.E., Shay J.W.;
RT   "H-ras expression in immortalized keratinocytes produces an invasive
RT   epithelium in cultured skin equivalents.";
RL   PLoS ONE 4:e7908.1-e7908.9(2009).
//