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Cellosaurus 402-91 (CVCL_S813)

[Text version]
Cell line name 402-91
Synonyms 402/91; MLS 402-91; MLS402
Accession CVCL_S813
Resource Identification Initiative To cite this cell line use: 402-91 (RRID:CVCL_S813)
Comments Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Omics: Variations; SNP array analysis.
Sequence variations
  • Gene fusion; HGNC; HGNC:2726; DDIT3 + HGNC; HGNC:4010; FUS; Name(s)=FUS-DDIT3, TLS-CHOP (PubMed=27270875).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (PubMed=27270875).
Disease Myxoid liposarcoma (NCIt: C27781)
Myxoid/round cell liposarcoma (ORDO: Orphanet_99967)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_S814 (402-91/ET)
Sex of cell Male
Category Transformed cell line
Publications

PubMed=1283316; DOI=10.1002/gcc.2870050403
Pierre Aman, David Ron, Nils Mandahl, Thoas Fioretos, Sverre Heim, Kristina Arheden, Helena Willen, Anders Rydholm, Felix Mitelman;
Rearrangement of the transcription factor gene CHOP in myxoid liposarcomas with t(12;16)(q13;p11).
Genes Chromosomes Cancer 5:278-285(1992)

PubMed=16651630; DOI=10.2353/ajpath.2006.050872; PMCID=PMC1606602
Katarina Engstrom, Helena Willen, Christina Kabjorn-Gustafsson, Carola Andersson, Marita Olsson, Melker Goransson, Sofia Thelin-Jarnum, Anita Olofsson, Elisabeth Warnhammar, Pierre Aman;
The myxoid/round cell liposarcoma fusion oncogene FUS-DDIT3 and the normal DDIT3 induce a liposarcoma phenotype in transfected human fibrosarcoma cells.
Am. J. Pathol. 168:1642-1653(2006)

PubMed=20515481; DOI=10.1186/1471-2407-10-249; PMCID=PMC2889895
Mattias K. Andersson, Melker Goransson, Anita Olofsson, Carola Andersson, Pierre Aman;
Nuclear expression of FLT1 and its ligand PGF in FUS-DDIT3 carrying myxoid liposarcomas suggests the existence of an intracrine signaling loop.
BMC Cancer 10:249.1-249.10(2010)

PubMed=24726063; DOI=10.1186/1756-9966-33-33; PMCID=PMC4022359
Christian Koelsche, Marcus Renner, Wolfgang Hartmann, Regine Brandt, Burkhard Lehner, Nina Waldburger, Ingo Alldinger, Thomas Schmitt, Gerlinde Egerer, Roland Penzel, Eva Wardelmann ...Show all 14 authors... , Peter Schirmacher, Andreas von Deimling, Gunhild Mechtersheimer; Show fewer authors
TERT promoter hotspot mutations are recurrent in myxoid liposarcomas but rare in other soft tissue sarcoma entities.
J. Exp. Clin. Cancer Res. 33:33.1-33.8(2014)

PubMed=25393000; DOI=10.1371/journal.pone.0113110; PMCID=PMC4231113
Anders Stahlberg, Christina Kabjorn-Gustafsson, Katarina Engtrom, Christer Thomsen, Soheila Dolatabadi, Emma Jonasson, Chieh-Yuan Li, David Ruff, Shiaw-Min Chen, Pierre Aman;
Normal and functional TP53 in genetically stable myxoid/round cell liposarcoma.
PLoS ONE 9:e113110.1-e113110.7(2014)

PubMed=26643872; DOI=10.18632/oncotarget.6464; PMCID=PMC4767443
Deepika Kanojia, Yasunobu Nagata, Manoj Garg, Dhong Hyun Lee, Aiko Sato, Kenichi Yoshida, Yusuke Sato, Masashi Sanada, Anand Mayakonda, Christoph Bartenhagen, Hans-Ulrich Klein ...Show all 28 authors... , Ngan B. Doan, Jonathan William Said, S. Mohith, Swetha Gunasekar, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Satoru Miyano, Ola Myklebost, Henry He Yang, Martin Dugas, Leonardo Andres Meza-Zepeda, Allan W. Silberman, Charles Forscher, Jeffrey W. Tyner, Seishi Ogawa, Harold Phillip Koeffler; Show fewer authors
Genomic landscape of liposarcoma.
Oncotarget 6:42429-42444(2015)

PubMed=27270875; DOI=10.1038/labinvest.2016.64; PMCID=PMC4965313
Marieke A. de Graaff, Jamie S.E. Yu, Hannah C. Beird, Davis R. Ingram, Theresa Nguyen, Jeffrey Jue-Hui Liu, Svetlana V. Bolshakov, Karoly Szuhai, Pierre Aman, Keila Enitt Torres, Dina Chelouche Lev ...Show all 15 authors... , Torsten O. Nielsen, Judith V.M.G. Bovee, Alexander J.F. Lazar, Neeta Somaiah; Show fewer authors
Establishment and characterization of a new human myxoid liposarcoma cell line (DL-221) with the FUS-DDIT3 translocation.
Lab. Invest. 96:885-894(2016)

PubMed=30962207; DOI=10.15252/embr.201845766; PMCID=PMC6500973
Malin Linden, Christer Thomsen, Pernilla Grundevik, Emma Jonasson, Daniel Andersson, Rikard Runnberg, Soheila Dolatabadi, Christoffer Vannas, Manuel Luna Santamaria, Henrik Fagman, Anders Stahlberg, Pierre Aman;
FET family fusion oncoproteins target the SWI/SNF chromatin remodeling complex.
EMBO Rep. 20:e45766.1-e45766.15(2019)

Cross-references
Encyclopedic resources Wikidata; Q54602862
Experimental variables resources EFO; EFO_0022655
Polymorphism and mutation databases Cosmic; 1105011
Cosmic; 1672267
Cosmic; 2307719
Cosmic; 2800529
Entry history
Entry creation03-Feb-2014
Last entry update10-Apr-2025
Version number18