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Cellosaurus T265 (CVCL_S805)

[Text version]
Cell line name T265
Synonyms T265-2c; T265-2C; T265p21
Accession CVCL_S805
Resource Identification Initiative To cite this cell line use: T265 (RRID:CVCL_S805)
Comments Problematic cell line: Contaminated. Shown to be a ST88-14 derivative (PubMed=36818284).
Doubling time: ~28 hours (PubMed=21084276).
Omics: Transcriptomics; Microarray.
Derived from site: In situ; Retroperitoneal space; UBERON=UBERON_0003693.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous; Note=By translocation (from parent cell line).
  • Gene deletion; HGNC; HGNC:7765; NF1; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7765; NF1; Simple; p.Arg304Ter (c.910C>T); ClinVar=VCV000187722; Zygosity=Heterozygous; Note=Germline (from parent cell line).
Disease Malignant peripheral nerve sheath tumor (NCIt: C3798)
Neurofibromatosis type 1 (NCIt: C3273)
Malignant peripheral nerve sheath tumor (ORDO: Orphanet_3148)
Neurofibromatosis type 1 (ORDO: Orphanet_636)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_8916 (ST88-14)
Sex of cell Male
Age at sampling 24Y
Category Cancer cell line
STR profile Source(s): PubMed=36818284

Markers:
AmelogeninX,Y
CSF1PO9,12
D2S133817,23
D3S135815,18
D5S81812,13
D7S8208
D8S117914
D13S31712
D16S53913
D18S5112
D19S43313,14
D21S1129,32.2
FGA21
TH019
TPOX11,12
vWA16

Run an STR similarity search on this cell line
Publications

PubMed=9766530; DOI=10.1002/(SICI)1097-4652(199811)177:2<334::AID-JCP15>3.0.CO;2-9
Ali Badache, George H. de Vries;
Neurofibrosarcoma-derived Schwann cells overexpress platelet-derived growth factor (PDGF) receptors and are induced to proliferate by PDGF BB.
J. Cell. Physiol. 177:334-342(1998)

PubMed=16429615; DOI=10.1017/S1740925X04000274; PMCID=PMC1325299
Philip R. Lee, Jonathan Eric Cohen, Elisabetta Anna Tendi, Robert Farrer, George H. de Vries, Kevin G. Becker, R. Douglas Fields;
Transcriptional profiling in an MPNST-derived cell line and normal human Schwann cells.
Neuron Glia Biol. 1:135-147(2004)

PubMed=16510576; DOI=10.1158/0008-5472.CAN-05-3330
Shyra J. Miller, Fatima Rangwala, Jon Williams, Peter Ackerman, Sue Kong, Anil G. Jegga, Sergio Kaiser, Bruce J. Aronow, Silke Frahm, Lan Kluwe, Victor-Felix Mautner ...Show all 20 authors... , Meena Upadhyaya, David F. Muir 4th, Margaret R. Wallace, Jussara Hagen, Dawn E. Quelle, Mark A. Watson, Arie Perry, David Hillel Gutmann, Nancy Ratner; Show fewer authors
Large-scale molecular comparison of human Schwann cells to malignant peripheral nerve sheath tumor cell lines and tissues.
Cancer Res. 66:2584-2591(2006)

PubMed=21084276; DOI=10.1158/0008-5472.CAN-10-2799; PMCID=PMC3064267
Gonzalo Lopez, Keila Enitt Torres, Jeffrey Jue-Hui Liu, Belinda Hernandez, Eric D. Young, Roman Belousov, Svetlana V. Bolshakov, Alexander J.F. Lazar, John M. Slopis, Ian E. McCutcheon, David J. McConkey, Dina Chelouche Lev;
Autophagic survival in resistance to histone deacetylase inhibitors: novel strategies to treat malignant peripheral nerve sheath tumors.
Cancer Res. 71:185-196(2011)

PubMed=22346343; DOI=10.4137/TOG.S8830; PMCID=PMC3273949
Dao-Chun Sun, Michael A. Tainsky, Ramsi Haddad;
Oncogene mutation survey in MPNST cell lines enhances the dominant role of hyperactive Ras in NF1 associated pro-survival and malignancy.
Transl. Oncogenomics 5:1-7(2012)

PubMed=24726063; DOI=10.1186/1756-9966-33-33; PMCID=PMC4022359
Christian Koelsche, Marcus Renner, Wolfgang Hartmann, Regine Brandt, Burkhard Lehner, Nina Waldburger, Ingo Alldinger, Thomas Schmitt, Gerlinde Egerer, Roland Penzel, Eva Wardelmann ...Show all 14 authors... , Peter Schirmacher, Andreas von Deimling, Gunhild Mechtersheimer; Show fewer authors
TERT promoter hotspot mutations are recurrent in myxoid liposarcomas but rare in other soft tissue sarcoma entities.
J. Exp. Clin. Cancer Res. 33:33.1-33.8(2014)

PubMed=28469964; PMCID=PMC5411799
Jian-Man Guo, Michael R. Grovola, Hong Xie, Grace E. Coggins, Patrick Duggan, Rukhsana Hasan, Jia-Le Huang, Danny W. Lin, Claire Song, Gabriela M. Witek, Simon Berritt ...Show all 13 authors... , David C. Schultz, Jeffrey Field; Show fewer authors
Comprehensive pharmacological profiling of neurofibromatosis cell lines.
Am. J. Cancer Res. 7:923-934(2017)

PubMed=32642732; DOI=10.1093/noajnl/vdz049; PMCID=PMC7317054
Alexander Pemov, Hua Li, William Presley, Margaret R. Wallace, David T. Miller;
Genetics of human malignant peripheral nerve sheath tumors.
Neurooncol. Adv. 2:i50-i61(2020)

PubMed=36818284; DOI=10.1016/j.isci.2023.106096; PMCID=PMC9929861
Miriam Magallon-Lorenz, Ernest Terribas, Sara Ortega-Bertran, Edgar Creus-Bachiller, Marco Fernandez, Gerard Requena, Inma Rosas, Helena Mazuelas, Itziar Uriarte-Arrazola, Alex Negro, Tereza Lausova ...Show all 28 authors... , Elisabeth Castellanos, Ignacio Blanco, George Henry DeVries, Hiroyuki Kawashima, Eric Legius, Hilde Brems, Victor-Felix Mautner, Lan Kluwe, Nancy Ratner, Margaret R. Wallace, Juana Fernandez-Rodriguez, Conxi Lazaro, Jonathan A. Fletcher, David E. Reuss, Meritxell Carrio, Bernat Gel, Eduard Serra; Show fewer authors
Deep genomic analysis of malignant peripheral nerve sheath tumor cell lines challenges current malignant peripheral nerve sheath tumor diagnosis.
iScience 26:106096.1-106096.22(2023)

Cross-references
Encyclopedic resources Wikidata; Q54971479
Experimental variables resources EFO; EFO_0006304
Polymorphism and mutation databases Cosmic; 1644552
Cosmic; 1801808
Cosmic; 2307730
Entry history
Entry creation03-Feb-2014
Last entry update10-Apr-2025
Version number14