• Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous; Note=By translocation (from parent cell line).
  
• Gene deletion; HGNC; HGNC:7765; NF1; Zygosity=Heterozygous (from parent cell line).
  
• Mutation; HGNC; HGNC:7765; NF1; Simple; p.Arg304Ter (c.910C>T); ClinVar=VCV000187722; Zygosity=Heterozygous; Note=Germline (from parent cell line).
  

PubMed=9766530; DOI=10.1002/(SICI)1097-4652(199811)177:2<334::AID-JCP15>3.0.CO;2-9
Badache A., de Vries G.H.
Neurofibrosarcoma-derived Schwann cells overexpress platelet-derived growth factor (PDGF) receptors and are induced to proliferate by PDGF BB.
J. Cell. Physiol. 177:334-342(1998)

PubMed=16429615; DOI=10.1017/S1740925X04000274; PMCID=PMC1325299
Lee P.R., Cohen J.E., Tendi E.A., Farrer R., de Vries G.H., Becker K.G., Fields R.D.
Transcriptional profiling in an MPNST-derived cell line and normal human Schwann cells.
Neuron Glia Biol. 1:135-147(2004)

PubMed=16510576; DOI=10.1158/0008-5472.CAN-05-3330
Miller S.J., Rangwala F., Williams J., Ackerman P., Kong S., Jegga A.G., Kaiser S., Aronow B.J., Frahm S., Kluwe L., Mautner V.-F., Upadhyaya M., Muir D.F. 4th, Wallace M.R., Hagen J., Quelle D.E., Watson M.A., Perry A., Gutmann D.H., Ratner N.
Large-scale molecular comparison of human Schwann cells to malignant peripheral nerve sheath tumor cell lines and tissues.
Cancer Res. 66:2584-2591(2006)

PubMed=21084276; DOI=10.1158/0008-5472.CAN-10-2799; PMCID=PMC3064267
Lopez G., Torres K.E., Liu J.J.-H., Hernandez B., Young E.D., Belousov R., Bolshakov S.V., Lazar A.J.F., Slopis J.M., McCutcheon I.E., McConkey D.J., Lev D.C.
Autophagic survival in resistance to histone deacetylase inhibitors: novel strategies to treat malignant peripheral nerve sheath tumors.
Cancer Res. 71:185-196(2011)

PubMed=22346343; DOI=10.4137/TOG.S8830; PMCID=PMC3273949
Sun D., Tainsky M.A., Haddad R.
Oncogene mutation survey in MPNST cell lines enhances the dominant role of hyperactive Ras in NF1 associated pro-survival and malignancy.
Transl. Oncogenomics 5:1-7(2012)

PubMed=24726063; DOI=10.1186/1756-9966-33-33; PMCID=PMC4022359
Koelsche C., Renner M., Hartmann W., Brandt R., Lehner B., Waldburger N., Alldinger I., Schmitt T., Egerer G., Penzel R., Wardelmann E., Schirmacher P., von Deimling A., Mechtersheimer G.
TERT promoter hotspot mutations are recurrent in myxoid liposarcomas but rare in other soft tissue sarcoma entities.
J. Exp. Clin. Cancer Res. 33:33.1-33.8(2014)

PubMed=28469964; PMCID=PMC5411799
Guo J.-M., Grovola M.R., Xie H., Coggins G.E., Duggan P., Hasan R., Huang J.-L., Lin D.W., Song C., Witek G.M., Berritt S., Schultz D.C., Field J.
Comprehensive pharmacological profiling of neurofibromatosis cell lines.
Am. J. Cancer Res. 7:923-934(2017)

PubMed=32642732; DOI=10.1093/noajnl/vdz049; PMCID=PMC7317054
Pemov A., Li H., Presley W., Wallace M.R., Miller D.T.
Genetics of human malignant peripheral nerve sheath tumors.
Neurooncol. Adv. 2:i50-i61(2020)

PubMed=36818284; DOI=10.1016/j.isci.2023.106096; PMCID=PMC9929861
Magallon-Lorenz M., Terribas E., Ortega-Bertran S., Creus-Bachiller E., Fernandez M., Requena G., Rosas I., Mazuelas H., Uriarte-Arrazola I., Negro A., Lausova T., Castellanos E., Blanco I., DeVries G.H., Kawashima H., Legius E., Brems H., Mautner V.-F., Kluwe L., Ratner N., Wallace M.R., Fernandez-Rodriguez J., Lazaro C., Fletcher J.A., Reuss D.E., Carrio M., Gel B., Serra E.
Deep genomic analysis of malignant peripheral nerve sheath tumor cell lines challenges current malignant peripheral nerve sheath tumor diagnosis.
iScience 26:106096.1-106096.22(2023)