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Cellosaurus FM3A SX10 (CVCL_S163)

[Text version]
Cell line name FM3A SX10
Synonyms SX10
Accession CVCL_S163
Resource Identification Initiative To cite this cell line use: FM3A SX10 (RRID:CVCL_S163)
Comments Characteristics: Radiation-sensitive. The parent cell line was irradiated with 2 Gy and this clone was hypersensitive to X-ray killing (PubMed=2426230).
Doubling time: 18.5 hours (PubMed=2426230); 24 hours (PubMed=7528891).
Selected for resistance to: NCIt; C17262; X-Ray.
Transformant: ChEBI; CHEBI_21759; N-methyl-N'-nitro-N-nitrosoguanidine (MNNG).
Derived from site: In situ; Mammary gland; UBERON=UBERON_0001911.
Sequence variations
  • Mutation; MGI; MGI:1335098; Lig4; Simple; p.Trp471Ter (c.1413G>A); Zygosity=Heterozygous (PubMed=11133995).
Disease Malignant neoplasms of the mouse mammary gland (NCIt: C21678)
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: C3H/He.
Hierarchy Parent: CVCL_S164 (FM3A SR-1)
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=2426230; DOI=10.20772/cancersci1985.77.5_456
Koki Sato, Akemi Ito, Tadahiro Shiomi, Hiroko Hama-Inaba, Hiroko Ishikawa, Takeo Yoshizumi, Tohru Nakazawa;
X-ray-sensitive mutants of mouse mammary carcinoma cells are hypersensitive to bleomycin and hydrogen peroxide.
Jpn. J. Cancer Res. 77:456-461(1986)

PubMed=7528891; DOI=10.1016/0921-8777(94)00036-6
Raymond L. Warters, Louis Raymond Barrows, David J. Chen;
DNA double-strand break repair in two radiation-sensitive mouse mammary carcinoma cell lines.
Mutat. Res. 336:1-7(1995)

PubMed=9582343; DOI=10.1074/jbc.273.21.13058
Ryutaro Fukumura, Ryoko Araki, Akira Fujimori, Masahiko Mori, Toshiyuki Saito, Fumiaki Watanabe, Mika Sarashi, Hiromi Itsukaichi, Kiyomi Eguchi-Kasai, Koki Sato, Kouichi Tatsumi, Masumi Abe;
Murine cell line SX9 bearing a mutation in the DNA-PKcs gene exhibits aberrant V(D)J recombination not only in the coding joint but also in the signal joint.
J. Biol. Chem. 273:13058-13064(1998)

PubMed=11133995; DOI=10.1074/jbc.M010530200
Katsuyuki Sado, Dai Ayusawa, Atsusi Enomoto, Tsutomu Suganuma, Mitsuo Oshimura, Koki Sato, Hideki Koyama;
Identification of a mutated DNA ligase IV gene in the X-ray-hypersensitive mutant SX10 of mouse FM3A cells.
J. Biol. Chem. 276:9742-9748(2001)

Cross-references
Encyclopedic resources Wikidata; Q54971262
Entry history
Entry creation05-Nov-2013
Last entry update14-Aug-2025
Version number10