ID   FM3A SX10
AC   CVCL_S163
SY   SX10
DR   Wikidata; Q54971262
RX   PubMed=2426230;
RX   PubMed=7528891;
RX   PubMed=9582343;
RX   PubMed=11133995;
CC   Characteristics: Radiation-sensitive. The parent cell line was irradiated with 2 Gy and this clone was hypersensitive to X-ray killing (PubMed=2426230).
CC   Doubling time: 18.5 hours (PubMed=2426230); 24 hours (PubMed=7528891).
CC   Selected for resistance to: NCIt; C17262; X-Ray.
CC   Sequence variation: Mutation; MGI; MGI:1335098; Lig4; Simple; p.Trp471Ter (c.1413G>A); Zygosity=Heterozygous (PubMed=11133995).
CC   Transformant: ChEBI; CHEBI:21759; N-methyl-N'-nitro-N-nitrosoguanidine (MNNG).
CC   Derived from site: In situ; Mammary gland; UBERON=UBERON_0001911.
CC   Breed/subspecies: C3H/He.
DI   NCIt; C21678; Malignant neoplasms of the mouse mammary gland
OX   NCBI_TaxID=10090; ! Mus musculus (Mouse)
HI   CVCL_S164 ! FM3A SR-1
SX   Female
CA   Cancer cell line
DT   Created: 05-11-13; Last updated: 29-06-23; Version: 8
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RX   PubMed=2426230; DOI=10.20772/cancersci1985.77.5_456;
RA   Sato K., Ito A., Shiomi T., Hama-Inaba H., Ishikawa H., Yoshizumi T.,
RA   Nakazawa T.;
RT   "X-ray-sensitive mutants of mouse mammary carcinoma cells are
RT   hypersensitive to bleomycin and hydrogen peroxide.";
RL   Jpn. J. Cancer Res. 77:456-461(1986).
//
RX   PubMed=7528891; DOI=10.1016/0921-8777(94)00036-6;
RA   Warters R.L., Barrows L.R., Chen D.J.;
RT   "DNA double-strand break repair in two radiation-sensitive mouse
RT   mammary carcinoma cell lines.";
RL   Mutat. Res. 336:1-7(1995).
//
RX   PubMed=9582343; DOI=10.1074/jbc.273.21.13058;
RA   Fukumura R., Araki R., Fujimori A., Mori M., Saito T., Watanabe F.,
RA   Sarashi M., Itsukaichi H., Eguchi-Kasai K., Sato K., Tatsumi K.,
RA   Abe M.;
RT   "Murine cell line SX9 bearing a mutation in the DNA-PKcs gene exhibits
RT   aberrant V(D)J recombination not only in the coding joint but also in
RT   the signal joint.";
RL   J. Biol. Chem. 273:13058-13064(1998).
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RX   PubMed=11133995; DOI=10.1074/jbc.M010530200;
RA   Sado K., Ayusawa D., Enomoto A., Suganuma T., Oshimura M., Sato K.,
RA   Koyama H.;
RT   "Identification of a mutated DNA ligase IV gene in the
RT   X-ray-hypersensitive mutant SX10 of mouse FM3A cells.";
RL   J. Biol. Chem. 276:9742-9748(2001).
//