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Cellosaurus HG23 (CVCL_RW46)

[Text version]
Cell line name HG23
Accession CVCL_RW46
Resource Identification Initiative To cite this cell line use: HG23 (RRID:CVCL_RW46)
Comments Population: Japanese.
Virology: Stably transfected with plasmid NV101, which contains a cloned cDNA consensus sequence of the RNA genome of Norwalk virus.
Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; 6307; KDR; Simple; p.Gln472His (c.1416A>T); ClinVar=VCV000134603; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 20932; POLD3; Simple; p.Lys109Arg (c.326A>G) (p.Lys70Arg, c.209A>G); Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Tyr220Cys (c.659A>G); ClinVar=VCV000127819; Zygosity=Homozygous (from parent cell line).
Disease Adult hepatocellular carcinoma (NCIt: C7956)
Adult hepatocellular carcinoma (ORDO: Orphanet_210159)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0336 (Huh-7)
Sex of cell Male
Age at sampling 57Y
Category Cancer cell line

PubMed=16843517; DOI=10.1016/j.virol.2006.06.006
Chang K.-O., Sosnovtsev S.V., Belliot G., King A.D., Green K.Y.
Stable expression of a Norwalk virus RNA replicon in a human hepatoma cell line.
Virology 353:463-473(2006)

PubMed=19515767; DOI=10.1128/JVI.00005-09
Chang K.-O.
Role of cholesterol pathways in norovirus replication.
J. Virol. 83:8587-8595(2009)

Cell line databases/resources cancercelllines; CVCL_RW46
Encyclopedic resources Wikidata; Q54885923
Gene expression databases GEO; GSM388886
GEO; GSM388887
GEO; GSM388888
Entry history
Entry creation05-Mar-2018
Last entry update05-Oct-2023
Version number11