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Cellosaurus NCI-H460-LNM35 (CVCL_RW33)

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Cell line name NCI-H460-LNM35
Synonyms LNM35
Accession CVCL_RW33
Resource Identification Initiative To cite this cell line use: NCI-H460-LNM35 (RRID:CVCL_RW33)
Comments Population: Caucasian.
Characteristics: Has lymphogenous metastactic properties. Consistently and spontaneously metastasizes to lymph nodes when injected either subcutaneously or orthotopically.
Omics: Transcriptomics; Microarray.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gln61His (c.183A>T); ClinVar=VCV000045117; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11389; STK11; Simple; p.Gln37Ter (c.109C>T); ClinVar=VCV000376334; Zygosity=Homozygous (from parent cell line).
Disease Lung large cell carcinoma (NCIt: C4450)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0459 (NCI-H460)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=10811136
Ken-ichi Kozaki, Osamu Miyaishi, Tetsuya Tsukamoto, Yoshio Tatematsu, Toyoaki Hida, Toshitada Takahashi, Takashi Takahashi;
Establishment and characterization of a human lung cancer cell line NCI-H460-LNM35 with consistent lymphogenous metastasis via both subcutaneous and orthotopic propagation.
Cancer Res. 60:2535-2540(2000)

PubMed=11464289; DOI=10.1038/sj.onc.1204561
Ken-ichi Kozaki, Katsumi Koshikawa, Yoshio Tatematsu, Osamu Miyaishi, Hiroko Saito, Toyoaki Hida, Hirotaka Osada, Takashi Takahashi;
Multi-faceted analyses of a highly metastatic human lung cancer cell line NCI-H460-LNM35 suggest mimicry of inflammatory cells in metastasis.
Oncogene 20:4228-4234(2001)

Cross-references
Cell line databases/resources cancercelllines; CVCL_RW33
Encyclopedic resources Wikidata; Q54908059
Entry history
Entry creation05-Mar-2018
Last entry update10-Apr-2025
Version number11