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Cellosaurus NCI-H460-LNM35 (CVCL_RW33)

[Text version]
Cell line name NCI-H460-LNM35
Synonyms LNM35
Accession CVCL_RW33
Resource Identification Initiative To cite this cell line use: NCI-H460-LNM35 (RRID:CVCL_RW33)
Comments Population: Caucasian.
Characteristics: Has lymphogenous metastactic properties. Consistently and spontaneously metastasizes to lymph nodes when injected either subcutaneously or orthotopically.
Omics: Transcriptome analysis by microarray.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gln61His (c.183A>T); ClinVar=VCV000045117; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11389; STK11; Simple; p.Gln37Ter (c.109C>T); ClinVar=VCV000376334; Zygosity=Homozygous (from parent cell line).
Disease Lung large cell carcinoma (NCIt: C4450)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0459 (NCI-H460)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line

Kozaki K.-I., Miyaishi O., Tsukamoto T., Tatematsu Y., Hida T., Takahashi T., Takahashi T.
Establishment and characterization of a human lung cancer cell line NCI-H460-LNM35 with consistent lymphogenous metastasis via both subcutaneous and orthotopic propagation.
Cancer Res. 60:2535-2540(2000)

PubMed=11464289; DOI=10.1038/sj.onc.1204561
Kozaki K.-I., Koshikawa K., Tatematsu Y., Miyaishi O., Saito H., Hida T., Osada H., Takahashi T.
Multi-faceted analyses of a highly metastatic human lung cancer cell line NCI-H460-LNM35 suggest mimicry of inflammatory cells in metastasis.
Oncogene 20:4228-4234(2001)

Cell line databases/resources cancercelllines; CVCL_RW33
Encyclopedic resources Wikidata; Q54908059
Entry history
Entry creation05-Mar-2018
Last entry update05-Oct-2023
Version number9