ID   NCI-H460-LNM35
AC   CVCL_RW33
SY   LNM35
DR   cancercelllines; CVCL_RW33
DR   Wikidata; Q54908059
RX   PubMed=10811136;
RX   PubMed=11464289;
CC   Population: Caucasian.
CC   Characteristics: Has lymphogenous metastactic properties. Consistently and spontaneously metastasizes to lymph nodes when injected either subcutaneously or orthotopically.
CC   Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gln61His (c.183A>T); ClinVar=VCV000045117; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11389; STK11; Simple; p.Gln37Ter (c.109C>T); ClinVar=VCV000376334; Zygosity=Homozygous (from parent cell line).
CC   Omics: Transcriptomics; Microarray.
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C4450; Lung large cell carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0459 ! NCI-H460
SX   Male
AG   Age unspecified
CA   Cancer cell line
DT   Created: 05-03-18; Last updated: 10-04-25; Version: 11
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RX   PubMed=10811136;
RA   Kozaki K.-i., Miyaishi O., Tsukamoto T., Tatematsu Y., Hida T.,
RA   Takahashi T., Takahashi T.;
RT   "Establishment and characterization of a human lung cancer cell line
RT   NCI-H460-LNM35 with consistent lymphogenous metastasis via both
RT   subcutaneous and orthotopic propagation.";
RL   Cancer Res. 60:2535-2540(2000).
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RX   PubMed=11464289; DOI=10.1038/sj.onc.1204561;
RA   Kozaki K.-i., Koshikawa K., Tatematsu Y., Miyaishi O., Saito H., Hida T.,
RA   Osada H., Takahashi T.;
RT   "Multi-faceted analyses of a highly metastatic human lung cancer cell
RT   line NCI-H460-LNM35 suggest mimicry of inflammatory cells in
RT   metastasis.";
RL   Oncogene 20:4228-4234(2001).
//