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Cellosaurus BT053 (CVCL_RU30)

[Text version]
Cell line name BT053
Synonyms BT53; BT-53
Accession CVCL_RU30
Resource Identification Initiative To cite this cell line use: BT053 (RRID:CVCL_RU30)
Comments Group: Cancer stem cell line.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Brain; UBERON=UBERON_0000955.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (PubMed=26095605).
Disease Glioblastoma (NCIt: C3058)
Glioblastoma (ORDO: Orphanet_360)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 59Y
Category Cancer cell line
Publications

PubMed=19544433; DOI=10.1002/stem.98
Kelly J.J.P., Stechishin O.D.M., Chojnacki A., Lun X.-Q., Sun B.-C., Senger D.L., Forsyth P., Auer R.N., Dunn J.F., Cairncross J.G., Parney I.F., Weiss S.
Proliferation of human glioblastoma stem cells occurs independently of exogenous mitogens.
Stem Cells 27:1722-1733(2009)

PubMed=26095605; DOI=10.1016/j.stemcr.2015.05.010
Cusulin C., Chesnelong C., Bose P., Bilenky M., Kopciuk K., Chan J.A.W., Cairncross J.G., Jones S.J.M., Marra M.A., Luchman H.A., Weiss S.
Precursor states of brain tumor initiating cell lines are predictive of survival in xenografts and associated with glioblastoma subtypes.
Stem Cell Reports 5:1-9(2015)

PubMed=27006494; DOI=10.1158/1078-0432.CCR-15-1798
Lun X.-Q., Wells J.C., Grinshtein N., King J.C., Hao X.-G., Dang N.-H., Wang X.-L., Aman A., Uehling D., Datti A., Wrana J.L., Easaw J.C., Luchman H.A., Weiss S., Cairncross J.G., Kaplan D.R., Robbins S.M., Senger D.L.
Disulfiram when combined with copper enhances the therapeutic effects of temozolomide for the treatment of glioblastoma.
Clin. Cancer Res. 22:3860-3875(2016)

Cross-references
Encyclopedic resources Wikidata; Q54798482
Entry history
Entry creation05-Mar-2018
Last entry update29-Jun-2023
Version number8