ID   BT053
AC   CVCL_RU30
SY   BT53; BT-53
DR   Wikidata; Q54798482
RX   PubMed=19544433;
RX   PubMed=26095605;
RX   PubMed=27006494;
CC   Group: Cancer stem cell line.
CC   Sequence variation: Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (PubMed=26095605).
CC   Omics: Transcriptomics; RNAseq.
CC   Derived from site: In situ; Brain; UBERON=UBERON_0000955.
DI   NCIt; C3058; Glioblastoma
DI   ORDO; Orphanet_360; Glioblastoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   59Y
CA   Cancer cell line
DT   Created: 05-03-18; Last updated: 10-04-25; Version: 10
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RX   PubMed=19544433; DOI=10.1002/stem.98;
RA   Kelly J.J.P., Stechishin O.D.M., Chojnacki A., Lun X.-Q., Sun B.-C.,
RA   Senger D.L., Forsyth P., Auer R.N., Dunn J.F., Cairncross J.G.,
RA   Parney I.F., Weiss S.;
RT   "Proliferation of human glioblastoma stem cells occurs independently
RT   of exogenous mitogens.";
RL   Stem Cells 27:1722-1733(2009).
//
RX   PubMed=26095605; DOI=10.1016/j.stemcr.2015.05.010; PMCID=PMC4618251;
RA   Cusulin C., Chesnelong C., Bose P., Bilenky M., Kopciuk K., Chan J.A.-W.,
RA   Cairncross J.G., Jones S.J.M., Marra M.A., Luchman H.A., Weiss S.;
RT   "Precursor states of brain tumor initiating cell lines are predictive
RT   of survival in xenografts and associated with glioblastoma
RT   subtypes.";
RL   Stem Cell Reports 5:1-9(2015).
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RX   PubMed=27006494; DOI=10.1158/1078-0432.CCR-15-1798;
RA   Lun X.-Q., Wells J.C., Grinshtein N., King J.C., Hao X.-G., Dang N.-H.,
RA   Wang X.-L., Aman A., Uehling D., Datti A., Wrana J.L., Easaw J.C.,
RA   Luchman H.A., Weiss S., Cairncross J.G., Kaplan D.R., Robbins S.M.,
RA   Senger D.L.;
RT   "Disulfiram when combined with copper enhances the therapeutic effects
RT   of temozolomide for the treatment of glioblastoma.";
RL   Clin. Cancer Res. 22:3860-3875(2016).
//