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Cellosaurus UOK262-WT (CVCL_RN43)

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Cell line name UOK262-WT
Synonyms 262FH+
Accession CVCL_RN43
Resource Identification Initiative To cite this cell line use: UOK262-WT (RRID:CVCL_RN43)
Comments Population: Caucasian.
Characteristics: Has a normal FH activity thanks to the transfection of the wild-type FH gene (PubMed=21907923).
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:3700; FH.
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Derived from site: Metastatic; Kidney; UBERON=UBERON_0002113.
Sequence variations
  • Gene deletion; HGNC; HGNC:3700; FH; Zygosity=Heterozygous; Note=Spontaneous loss of heterozygosity (from parent cell line).
  • Mutation; HGNC; HGNC:3700; FH; Simple; p.Gln439Pro (c.1316A>C); ClinVar=VCV003230435; Zygosity=Heterozygous (from parent cell line).
Disease Hereditary leiomyomatosis and renal cell carcinoma (NCIt: C51302)
Hereditary leiomyomatosis and renal cell cancer (ORDO: Orphanet_523)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1D72 (UOK262)
Sex of cell Female
Age at sampling 48Y
Category Cancer cell line
Publications

PubMed=21907923; DOI=10.1016/j.ccr.2011.07.018; PMCID=PMC3174047
Wing-Hang Tong, Carole Sourbier, Gennady Kovtunovych, Suh Young Jeong, Manish A. Vira, Manik Ghosh, Vladimir Valera Romero, Rachid Sougrat, Sophie Vaulont, Benoit Viollet, Yeong-Sang Kim ...Show all 18 authors... , Sunmin Lee, Jane B. Trepel, Ramaprasad Srinivasan, Gennady Bratslavsky, You-Feng Yang, William Marston Linehan, Tracey Ann Rouault; Show fewer authors
The glycolytic shift in fumarate-hydratase-deficient kidney cancer lowers AMPK levels, increases anabolic propensities and lowers cellular iron levels.
Cancer Cell 20:315-327(2011)

PubMed=22867999; DOI=10.1016/j.cancergen.2012.05.001; PMCID=PMC3415708
You-Feng Yang, Vladimir A. Valera, Carole Sourbier, Cathy D. Vocke, Ming-Hui Wei, Lisa Pike, Ying Huang, Maria J. Merino, Gennady Bratslavsky, Min Wu, Christopher J. Ricketts, William Marston Linehan;
A novel fumarate hydratase-deficient HLRCC kidney cancer cell line, UOK268: a model of the Warburg effect in cancer.
Cancer Genet. 205:377-390(2012)

Cross-references
Encyclopedic resources Wikidata; Q54991418
Entry history
Entry creation05-Mar-2018
Last entry update14-Aug-2025
Version number12