ID   UOK262-WT
AC   CVCL_RN43
SY   262FH+
DR   Wikidata; Q54991418
RX   PubMed=21907923;
RX   PubMed=22867999;
CC   Population: Caucasian.
CC   Characteristics: Has a normal FH activity thanks to the transfection of the wild-type FH gene (PubMed=21907923).
CC   Sequence variation: Gene deletion; HGNC; HGNC:3700; FH; Zygosity=Heterozygous; Note=Spontaneous loss of heterozygosity (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:3700; FH; Simple; p.Gln439Pro (c.1316A>C); ClinVar=VCV003230435; Zygosity=Heterozygous (from parent cell line).
CC   Genetic integration: Method=Transfection; Gene=HGNC; HGNC:3700; FH.
CC   Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Transposon Tn5 neo.
CC   Derived from site: Metastatic; Kidney; UBERON=UBERON_0002113.
DI   NCIt; C51302; Hereditary leiomyomatosis and renal cell carcinoma
DI   ORDO; Orphanet_523; Hereditary leiomyomatosis and renal cell cancer
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1D72 ! UOK262
SX   Female
AG   48Y
CA   Cancer cell line
DT   Created: 05-03-18; Last updated: 10-04-25; Version: 11
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RX   PubMed=21907923; DOI=10.1016/j.ccr.2011.07.018; PMCID=PMC3174047;
RA   Tong W.-H., Sourbier C., Kovtunovych G., Jeong S.Y., Vira M.A., Ghosh M.,
RA   Romero V.V., Sougrat R., Vaulont S., Viollet B., Kim Y.-S., Lee S.,
RA   Trepel J.B., Srinivasan R., Bratslavsky G., Yang Y.-F., Linehan W.M.,
RA   Rouault T.A.;
RT   "The glycolytic shift in fumarate-hydratase-deficient kidney cancer
RT   lowers AMPK levels, increases anabolic propensities and lowers
RT   cellular iron levels.";
RL   Cancer Cell 20:315-327(2011).
//
RX   PubMed=22867999; DOI=10.1016/j.cancergen.2012.05.001; PMCID=PMC3415708;
RA   Yang Y.-F., Valera V.A., Sourbier C., Vocke C.D., Wei M.-H., Pike L.,
RA   Huang Y., Merino M.J., Bratslavsky G., Wu M., Ricketts C.J.,
RA   Linehan W.M.;
RT   "A novel fumarate hydratase-deficient HLRCC kidney cancer cell line,
RT   UOK268: a model of the Warburg effect in cancer.";
RL   Cancer Genet. 205:377-390(2012).
//