| Cell line name |
LNCaP-CL2 |
|---|
| Synonyms |
CL2; CL-2 |
|---|
| Accession |
CVCL_RK71 |
|---|
| Resource Identification Initiative |
To cite this cell line use: LNCaP-CL2 (RRID:CVCL_RK71) |
|---|
| Comments |
Population: Caucasian.
Derived from site: Metastatic; Left supraclavicular lymph node; UBERON=UBERON_8480056. |
|---|
| Sequence variations |
- Mutation; HGNC; HGNC:644; AR; Simple; p.Thr878Ala (c.2632A>G); ClinVar=VCV000009831; Zygosity=Hemizygous (from parent cell line).
- Mutation; HGNC; HGNC:7010; MEN1; Simple; p.Tyr318Ter (c.954T>G) (p.Tyr313Ter, c.939T>A); ClinVar=VCV000439894; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:8979; PIK3R1; Simple; p.Arg639Ter (c.1915C>T); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Lys6Argfs*4 (c.17_18delAA); ClinVar=VCV000231649; Zygosity=Unspecified (from parent cell line).
|
|---|
| Disease |
Prostate carcinoma (NCIt: C4863) |
|---|
| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
|---|
| Hierarchy |
Parent: CVCL_3872 (LNCaP-CL1) |
|---|
| Sex of cell |
Male |
|---|
| Age at sampling |
50Y |
|---|
| Category |
Cancer cell line |
|---|
| Publications | PubMed=11038142
Cho-Lea Tso, William H. McBride, Ji-Rong Sun, Belur Janakray Patel, Ke-Hung Tsui, Sun H. Paik, Barbara Gitlitz, Randy Caliliw, Arndt van Ophoven, Lily Wu, Jean B. deKernion, Arie S. Belldegrun;
Androgen deprivation induces selective outgrowth of aggressive hormone-refractory prostate cancer clones expressing distinct cellular and molecular properties not present in parental androgen-dependent cancer cells.
Cancer J. Sci. Am. 6:220-233(2000) |
|---|
| Cross-references |
|---|
| Cell line databases/resources |
cancercelllines; CVCL_RK71
|
|---|
| Encyclopedic resources |
Wikidata; Q54902834
|
|---|
| Entry history |
|---|
| Entry creation | 05-Mar-2018 |
|---|
| Last entry update | 19-Dec-2024 |
|---|
| Version number | 11 |
|---|
