ID   LNCaP-CL2
AC   CVCL_RK71
SY   CL2; CL-2
DR   cancercelllines; CVCL_RK71
DR   Wikidata; Q54902834
RX   PubMed=11038142;
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; 644; AR; Simple; p.Thr878Ala (c.2632A>G); ClinVar=VCV000009831; Zygosity=Hemizygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7010; MEN1; Simple; p.Tyr318Ter (c.954T>G) (p.Tyr313Ter, c.939T>A); ClinVar=VCV000439894; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 8979; PIK3R1; Simple; p.Arg639Ter (c.1915C>T); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 9588; PTEN; Simple; p.Lys6Argfs*4 (c.17_18delAA); ClinVar=VCV000231649; Zygosity=Unspecified (from parent cell line).
CC   Derived from site: Metastatic; Left supraclavicular lymph node; UBERON=UBERON_8480056.
DI   NCIt; C4863; Prostate carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_3872 ! LNCaP-CL1
SX   Male
AG   50Y
CA   Cancer cell line
DT   Created: 05-03-18; Last updated: 05-10-23; Version: 10
//
RX   PubMed=11038142;
RA   Tso C.-L., McBride W.H., Sun J.-R., Patel B.J., Tsui K.-H., Paik S.H.,
RA   Gitlitz B., Caliliw R., van Ophoven A., Wu L., deKernion J.B.,
RA   Belldegrun A.S.;
RT   "Androgen deprivation induces selective outgrowth of aggressive
RT   hormone-refractory prostate cancer clones expressing distinct cellular
RT   and molecular properties not present in parental androgen-dependent
RT   cancer cells.";
RL   Cancer J. Sci. Am. 6:220-233(2000).
//