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Cellosaurus HCC1937 shPARG (CVCL_RA87)

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Cell line name HCC1937 shPARG
Synonyms shPARG HCC1937
Accession CVCL_RA87
Resource Identification Initiative To cite this cell line use: HCC1937 shPARG (RRID:CVCL_RA87)
Comments Group: Triple negative breast cancer (TNBC) cell line.
Population: Caucasian.
Knockout cell: Method=shRNA knockdown; HGNC; HGNC:8605; PARG.
Omics: Proteomics; PTM; Poly-ADP-ribosylation.
Derived from site: In situ; Breast; UBERON=UBERON_0000310.
Sequence variations
  • Gene deletion; HGNC; HGNC:9588; PTEN; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1100; BRCA1; Simple; p.Gln1756Profs*74 (c.5266dupC) (5382insC); ClinVar=VCV000017677; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9884; RB1; Simple; p.Thr738_Arg775del38 (c.2212_2325del114); Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg306Ter (c.916C>T); ClinVar=VCV000142144; Zygosity=Homozygous (from parent cell line).
Disease Breast ductal carcinoma (NCIt: C4017)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0290 (HCC1937)
Sex of cell Female
Age at sampling 24Y
Category Cancer cell line
Publications

PubMed=29166620; DOI=10.1016/j.celrep.2017.10.106; PMCID=PMC5728415
Yuan-Li Zhen, Ya-Jie Zhang, Yong-Hao Yu;
A cell-line-specific atlas of PARP-mediated protein Asp/Glu-ADP-ribosylation in breast cancer.
Cell Rep. 21:2326-2337(2017)

Cross-references
Cell line databases/resources cancercelllines; CVCL_RA87
Encyclopedic resources Wikidata; Q54881613
Entry history
Entry creation05-Mar-2018
Last entry update10-Apr-2025
Version number15