ID   HCC1937 shPARG
AC   CVCL_RA87
SY   shPARG HCC1937
DR   cancercelllines; CVCL_RA87
DR   Wikidata; Q54881613
RX   PubMed=29166620;
CC   Group: Triple negative breast cancer (TNBC) cell line.
CC   Population: Caucasian.
CC   Knockout cell: Method=shRNA knockdown; HGNC; HGNC:8605; PARG.
CC   Sequence variation: Gene deletion; HGNC; HGNC:9588; PTEN; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:1100; BRCA1; Simple; p.Gln1756Profs*74 (c.5266dupC) (5382insC); ClinVar=VCV000017677; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:9884; RB1; Simple; p.Thr738_Arg775del38 (c.2212_2325del114); Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg306Ter (c.916C>T); ClinVar=VCV000142144; Zygosity=Homozygous (from parent cell line).
CC   Omics: Proteomics; PTM; Poly-ADP-ribosylation.
CC   Derived from site: In situ; Breast; UBERON=UBERON_0000310.
DI   NCIt; C4017; Breast ductal carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0290 ! HCC1937
SX   Female
AG   24Y
CA   Cancer cell line
DT   Created: 05-03-18; Last updated: 10-04-25; Version: 15
//
RX   PubMed=29166620; DOI=10.1016/j.celrep.2017.10.106; PMCID=PMC5728415;
RA   Zhen, Yuan-Li
RA   Zhang, Ya-Jie
RA   Yu, Yong-Hao
RT   "A cell-line-specific atlas of PARP-mediated protein
RT   Asp/Glu-ADP-ribosylation in breast cancer.";
RL   Cell Rep. 21:2326-2337(2017).
//