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Cellosaurus VCaP-EnzR (CVCL_RA58)

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Cell line name VCaP-EnzR
Accession CVCL_RA58
Resource Identification Initiative To cite this cell line use: VCaP-EnzR (RRID:CVCL_RA58)
Comments Population: Caucasian.
Virology: Contains an integrated xenotropic MuLV-related virus (XMRV) Bxv-1 (from parent cell line).
Selected for resistance to: ChEBI; CHEBI_68534; Enzalutamide (Xtandi; MDV-3100).
Omics: Transcriptomics; Microarray.
Derived from site: Metastatic; Bone, vertebra; UBERON=UBERON_0002412.
Sequence variations
  • Gene fusion; HGNC; HGNC:3446; ERG + HGNC; HGNC:11876; TMPRSS2; Name(s)=TMPRSS2-ERG (from parent cell line).
  • Mutation; HGNC; HGNC:7127; MLH1; Simple; p.Ile219Val (c.655A>G); ClinVar=VCV000036557; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Trp (c.742C>T); ClinVar=VCV000012347; Zygosity=Homozygous (from parent cell line).
Disease Prostate carcinoma (NCIt: C4863)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2235 (VCaP)
Sex of cell Male
Age at sampling 59Y
Category Cancer cell line
STR profile Source(s): Millipore=SCC421

Markers:
AmelogeninX,Y
CSF1PO10,12
D3S135814,15
D5S81812
D7S8209,12
D8S117912,13
D13S31711,12
D16S5399
D18S5113
D21S1131
FGA21,26
Penta D9
Penta E10,12
TH019.3
TPOX8,11
vWA18,19

Run an STR similarity search on this cell line
Publications

PubMed=27036029; DOI=10.18632/oncotarget.8456; PMCID=PMC5041979
Steven Kregel, James L. Chen, Westin Tom, Venkatesh Krishnan, Jacob Kach, Hannah Brechka, Tim B. Fessenden, Masis Isikbay, Gladell Pador Paner, Russell Z. Szmulewitz, Donald J. Vander Griend;
Acquired resistance to the second-generation androgen receptor antagonist enzalutamide in castration-resistant prostate cancer.
Oncotarget 7:26259-26274(2016)

Cross-references
Cell line collections (Providers) Millipore; SCC421
Cell line databases/resources cancercelllines; CVCL_RA58
Encyclopedic resources Wikidata; Q54992965
Gene expression databases GEO; GSM2069538
GEO; GSM2069539
GEO; GSM2069540
GEO; GSM2069541
Entry history
Entry creation05-Mar-2018
Last entry update10-Apr-2025
Version number18