ID   VCaP-EnzR
AC   CVCL_RA58
DR   cancercelllines; CVCL_RA58
DR   GEO; GSM2069538
DR   GEO; GSM2069539
DR   GEO; GSM2069540
DR   GEO; GSM2069541
DR   Millipore; SCC421
DR   Wikidata; Q54992965
RX   PubMed=27036029;
CC   Population: Caucasian.
CC   Virology: Contains an integrated xenotropic MuLV-related virus (XMRV) Bxv-1 (from parent cell line).
CC   Selected for resistance to: ChEBI; CHEBI:68534; Enzalutamide (Xtandi; MDV-3100).
CC   Sequence variation: Gene fusion; HGNC; 3446; ERG + HGNC; 11876; TMPRSS2; Name(s)=TMPRSS2-ERG (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7127; MLH1; Simple; p.Ile219Val (c.655A>G); ClinVar=VCV000036557; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg248Trp (c.742C>T); ClinVar=VCV000012347; Zygosity=Homozygous (from parent cell line).
CC   Omics: Transcriptome analysis by microarray.
CC   Derived from site: Metastatic; Bone, vertebra; UBERON=UBERON_0002412.
ST   Source(s): Millipore=SCC421
ST   Amelogenin: X,Y
ST   CSF1PO: 10,12
ST   D13S317: 11,12
ST   D16S539: 9
ST   D18S51: 13
ST   D21S11: 31
ST   D3S1358: 14,15
ST   D5S818: 12
ST   D7S820: 9,12
ST   D8S1179: 12,13
ST   FGA: 21,26
ST   Penta D: 9
ST   Penta E: 10,12
ST   TH01: 9.3
ST   TPOX: 8,11
ST   vWA: 18,19
DI   NCIt; C4863; Prostate carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_2235 ! VCaP
SX   Male
AG   59Y
CA   Cancer cell line
DT   Created: 05-03-18; Last updated: 02-05-24; Version: 16
//
RX   PubMed=27036029; DOI=10.18632/oncotarget.8456; PMCID=PMC5041979;
RA   Kregel S., Chen J.L., Tom W., Krishnan V., Kach J., Brechka H.,
RA   Fessenden T.B., Isikbay M., Paner G.P., Szmulewitz R.Z.,
RA   Vander Griend D.J.;
RT   "Acquired resistance to the second-generation androgen receptor
RT   antagonist enzalutamide in castration-resistant prostate cancer.";
RL   Oncotarget 7:26259-26274(2016).
//