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Cellosaurus MEF3.8/T6400 (CVCL_R998)

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Cell line name MEF3.8/T6400
Synonyms Mef3.8/T6400; T6400
Accession CVCL_R998
Resource Identification Initiative To cite this cell line use: MEF3.8/T6400 (RRID:CVCL_R998)
Comments Knockout cell: Method=KO mouse; MGI; MGI:97570; Abcb1a.
Knockout cell: Method=KO mouse; MGI; MGI:97568; Abcb1b.
Knockout cell: Method=KO mouse; MGI; MGI:102676; Abcc1.
Selected for resistance to: ChEBI; CHEBI_63632; Topotecan.
Derived from site: In situ; Embryo; UBERON=UBERON_0000922.
Cell type: Fibroblast; CL=CL_0000057.
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Hierarchy Parent: CVCL_R997 (MEF3.8)
Sex of cell Sex unspecified
Age at sampling Embryo
Category Spontaneously immortalized cell line
Publications

PubMed=10485464
John D. Allen, Remco F. Brinkhuis, Jan Wijnholds, Alfred H. Schinkel;
The mouse Bcrp1/Mxr/Abcp gene: amplification and overexpression in cell lines selected for resistance to topotecan, mitoxantrone, or doxorubicin.
Cancer Res. 59:4237-4241(1999)

PubMed=11956086
John D. Allen, Sonja C. Jackson, Alfred H. Schinkel;
A mutation hot spot in the Bcrp1 (Abcg2) multidrug transporter in mouse cell lines selected for doxorubicin resistance.
Cancer Res. 62:2294-2299(2002)

Cross-references
Chemistry resources ChEMBL-Cells; CHEMBL3307255
ChEMBL-Targets; CHEMBL613094
PubChem_Cell_line; CVCL_R998
Encyclopedic resources Wikidata; Q54905034
Entry history
Entry creation05-Nov-2013
Last entry update19-Dec-2024
Version number10