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Cellosaurus A431 YAP-5SA (CVCL_QX12)

[Text version]
Cell line name A431 YAP-5SA
Synonyms YAP_5SA_A431
Accession CVCL_QX12
Resource Identification Initiative To cite this cell line use: A431 YAP-5SA (RRID:CVCL_QX12)
Comments Population: Caucasian.
Transfected with: HGNC; 16262; YAP1 (with p.Ser61Ala, p.Ser109Ala, p.Ser127Ala, p.Ser164Ala and p.Ser381Ala = YAP-5SA).
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Skin, epidermis; UBERON=UBERON_0001003.
Sequence variations
  • Gene fusion; HGNC; 3236; EGFR + HGNC; 9237; PPARGC1A; Name(s)=EGFR-PPARGC1A (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Unspecified (from parent cell line).
Disease Skin squamous cell carcinoma (NCIt: C4819)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0037 (A-431)
Sex of cell Female
Age at sampling 85Y
Category Cancer cell line

PubMed=26989177; DOI=10.1242/dev.133728
Elbediwy A., Vincent-Mistiaen Z.I., Spencer-Dene B., Stone R.K., Boeing S., Wculek S.K., Cordero J., Tan E.H., Ridgway R., Brunton V.G., Sahai E., Gerhardt H., Behrens A., Malanchi I., Sansom O.J., Thompson B.J.
Integrin signalling regulates YAP and TAZ to control skin homeostasis.
Development 143:1674-1687(2016)

Cell line databases/resources cancercelllines; CVCL_QX12
Encyclopedic resources Wikidata; Q54606913
Gene expression databases GEO; GSM2112556
GEO; GSM2112557
GEO; GSM2112558
Entry history
Entry creation15-Nov-2017
Last entry update05-Oct-2023
Version number13