Cellosaurus cell line A431 YAP-5SA (CVCL

Cellosaurus A431 YAP-5SA (CVCL_QX12)

Cross-references
Cell line name	A431 YAP-5SA
Synonyms	YAP_5SA_A431
Accession	CVCL_QX12
Resource Identification Initiative	To cite this cell line use: A431 YAP-5SA (RRID:CVCL_QX12)
Comments	Population: Caucasian. Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:16262; YAP1 (Note=With p.Ser61Ala, p.Ser109Ala, p.Ser127Ala, p.Ser164Ala and p.Ser381Ala = YAP-5SA). Omics: Transcriptomics; RNAseq. Derived from site: In situ; Skin, epidermis; UBERON=UBERON_0001003.
Sequence variations	Gene fusion; HGNC; HGNC:3236; EGFR + HGNC; HGNC:9237; PPARGC1A; Name(s)=EGFR-PPARGC1A (from parent cell line). Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Unspecified (from parent cell line).
Disease	Skin squamous cell carcinoma (NCIt: C4819)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_0037 (A-431)
Sex of cell	Female
Age at sampling	85Y
Category	Cancer cell line
Publications	PubMed=26989177; DOI=10.1242/dev.133728; PMCID=PMC4874484 Ahmed Elbediwy, Zoe I. Vincent-Mistiaen, Bradley Spencer-Dene, Richard K. Stone, Stefan Boeing, Stefanie Kristin Wculek, Julia Cordero, Ee H. Tan, Rachel Ridgway, Valerie G. Brunton, Erik Sahai ...Show all 16 authors... , Holger Gerhardt, Axel Behrens, Ilaria Malanchi, Owen James Sansom, Barry J. Thompson; Show fewer authors Integrin signalling regulates YAP and TAZ to control skin homeostasis. Development 143:1674-1687(2016)
Cell line databases/resources	cancercelllines; CVCL_QX12
Encyclopedic resources	Wikidata; Q54606913
Gene expression databases	GEO; GSM2112556 GEO; GSM2112557 GEO; GSM2112558
Entry history
Entry creation	15-Nov-2017
Last entry update	10-Apr-2025
Version number	16