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Cellosaurus A431 YAP-5SA (CVCL_QX12)

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Cell line name A431 YAP-5SA
Synonyms YAP_5SA_A431
Accession CVCL_QX12
Resource Identification Initiative To cite this cell line use: A431 YAP-5SA (RRID:CVCL_QX12)
Comments Population: Caucasian.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:16262; YAP1 (Note=With p.Ser61Ala, p.Ser109Ala, p.Ser127Ala, p.Ser164Ala and p.Ser381Ala = YAP-5SA).
Omics: Transcriptomics; RNAseq.
Derived from site: In situ; Skin, epidermis; UBERON=UBERON_0001003.
Sequence variations
  • Gene fusion; HGNC; HGNC:3236; EGFR + HGNC; HGNC:9237; PPARGC1A; Name(s)=EGFR-PPARGC1A (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Unspecified (from parent cell line).
Disease Skin squamous cell carcinoma (NCIt: C4819)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0037 (A-431)
Sex of cell Female
Age at sampling 85Y
Category Cancer cell line
Publications

PubMed=26989177; DOI=10.1242/dev.133728; PMCID=PMC4874484
Ahmed Elbediwy, Zoe I. Vincent-Mistiaen, Bradley Spencer-Dene, Richard K. Stone, Stefan Boeing, Stefanie Kristin Wculek, Julia Cordero, Ee H. Tan, Rachel Ridgway, Valerie G. Brunton, Erik Sahai ...Show all 16 authors... , Holger Gerhardt, Axel Behrens, Ilaria Malanchi, Owen James Sansom, Barry J. Thompson; Show fewer authors
Integrin signalling regulates YAP and TAZ to control skin homeostasis.
Development 143:1674-1687(2016)

Cross-references
Cell line databases/resources cancercelllines; CVCL_QX12
Encyclopedic resources Wikidata; Q54606913
Gene expression databases GEO; GSM2112556
GEO; GSM2112557
GEO; GSM2112558
Entry history
Entry creation15-Nov-2017
Last entry update10-Apr-2025
Version number16