Cellosaurus cell line 2L1 (CVCL

Cross-references
Cell line name	2L1
Accession	CVCL_QW59
Resource Identification Initiative	To cite this cell line use: 2L1 (RRID:CVCL_QW59)
Comments	Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Sequence variations	Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg306Ter (c.916C>T); ClinVar=VCV000142144; Zygosity=Unspecified; Note=Germline (PubMed=9616138).
Disease	Therapy-related acute myeloid leukemia (NCIt: C8252) Therapy related acute myeloid leukemia and myelodysplastic syndrome (ORDO: Orphanet_86846)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell	Female
Age at sampling	4Y
Category	Cancer cell line
Publications	PubMed=9616138; DOI=10.1182/blood.V91.12.4451 Carolyn A. Felix, Maureen D. Megonigal, David S. Chervinsky, Debra G.B. Leonard, Nao Tsuchida, Surabhi Kakati, AnneMarie W. Block, John Fisher, Mauro Grossi, Kevin Earl Salhany, Sheila N. Jani Sait, Peter D. Aplan; Association of germline p53 mutation with MLL segmental jumping translocation in treatment-related leukemia. Blood 91:4451-4456(1998) PubMed=14671638; DOI=10.1038/sj.leu.2403236 Hans Gunther Drexler, Hilmar Quentmeier, Roderick A.F. MacLeod; Malignant hematopoietic cell lines: in vitro models for the study of MLL gene alterations. Leukemia 18:227-232(2004)
Cell line databases/resources	cancercelllines; CVCL_QW59
Encyclopedic resources	Wikidata; Q54584593
Entry history
Entry creation	15-Nov-2017
Last entry update	19-Dec-2024
Version number	12