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Cellosaurus MOVP-3 (CVCL_N031)

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Cell line name MOVP-3
Accession CVCL_N031
Resource Identification Initiative To cite this cell line use: MOVP-3 (RRID:CVCL_N031)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_4911; Etoposide (VP-16).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
  • Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Leu1600Pro (c.4799T>C); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Pro2514Argfs*4 (c.7541_7542delCT); ClinVar=VCV000581973; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Lys267Argfs*9 (c.800delA) (p.Leu265fs, c.795delA); ClinVar=VCV000092828; Zygosity=Homozygous (from parent cell line).
Disease Adult T acute lymphoblastic leukemia (NCIt: C9142)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0624 (MOLT-3)
Sex of cell Male
Age at sampling 19Y
Category Cancer cell line
Publications

PubMed=12623853; DOI=10.1182/blood-2002-07-2268
Ulrike Schroeder, Kathrin Maria Bernt, Bjorn Lange, Jens Wenkel, Jiang Jikai, Doron Shabat, Roey Amir, Nicole Huebener, Andreas G. Niethammer, Christian Hagemeier, Luder Wiebusch ...Show all 15 authors... , Gerhard Gaedicke, Wolfgang Wrasidlo, Ralph Alfred Reisfeld, Holger N. Lode; Show fewer authors
Hydrolytically activated etoposide prodrugs inhibit MDR-1 function and eradicate established MDR-1 multidrug-resistant T-cell leukemia.
Blood 102:246-253(2003)

Cross-references
Cell line databases/resources cancercelllines; CVCL_N031
Chemistry resources ChEMBL-Cells; CHEMBL3307302
ChEMBL-Targets; CHEMBL614133
PubChem_Cell_line; CVCL_N031
Encyclopedic resources Wikidata; Q54906419
Entry history
Entry creation05-Nov-2013
Last entry update19-Dec-2024
Version number17