Cellosaurus logo
expasy logo

Cellosaurus LPS141 (CVCL_M823)

[Text version]
Cell line name LPS141
Synonyms LS141
Accession CVCL_M823
Resource Identification Initiative To cite this cell line use: LPS141 (RRID:CVCL_M823)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
From: Fletcher, Jonathan A.; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School; Boston; USA.
Omics: Transcriptomics; Microarray.
Omics: Variations; SNP array analysis.
Disease Dedifferentiated liposarcoma (NCIt: C3704)
Dedifferentiated liposarcoma (ORDO: Orphanet_99970)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): DepMap=ACH-001799

Markers:
AmelogeninX
CSF1PO11,12
D3S135817
D5S81812
D7S82011,12
D8S117911,13
D13S31713
D16S53912,14
D18S5111,14
D21S1128,29
FGA23
Penta D9,13
Penta E11,12
TH019.3
TPOX8,11
vWA16,17

Run an STR similarity search on this cell line
Publications

PubMed=19449367; DOI=10.1002/path.2564
Eric Lee Snyder, Deborah J. Sandstrom, Kenneth Law, Christopher Fiore, Ewa T. Sicinska, Joseph Brito, Dyane Bailey, Jonathan A. Fletcher, Massimo Loda, Scott J. Rodig, Paola S. Dal Cin, Christopher David Marsden Fletcher;
c-Jun amplification and overexpression are oncogenic in liposarcoma but not always sufficient to inhibit the adipocytic differentiation programme.
J. Pathol. 218:292-300(2009)

PubMed=19706776; DOI=10.1158/0008-5472.CAN-08-4004; PMCID=PMC2905726
Thomas Muhlenberg, Yi-Xiang Zhang, Andrew J. Wagner, Florian Grabellus, James E. Bradner, Georg Taeger, Hauke Lang, Takahiro Taguchi, Martin Schuler, Jonathan A. Fletcher, Sebastian Bauer;
Inhibitors of deacetylases suppress oncogenic KIT signaling, acetylate HSP90, and induce apoptosis in gastrointestinal stromal tumors.
Cancer Res. 69:6941-6950(2009)

PubMed=20713527; DOI=10.1158/0008-5472.CAN-10-0745; PMCID=PMC3266950
Elliott R. Brill, Ryan M. Gobble, Christina V. Angeles, Mariana Lagos-Quintana, Aimee Marie Crago, Bernadette Uy Laxa, Penelope Lee DeCarolis, Lei Zhang, Cristina R. Antonescu, Nicholas Donald Socci, Barry Stephen Taylor ...Show all 14 authors... , Chris Sander, Andrew Koff, Samuel Singer; Show fewer authors
ZIC1 overexpression is oncogenic in liposarcoma.
Cancer Res. 70:6891-6901(2010)

PubMed=21335544; DOI=10.1158/0008-5472.CAN-10-3588; PMCID=PMC3070774
Ryan M. Gobble, Li-Xuan Qin, Elliott R. Brill, Christina V. Angeles, Stacy Ugras, Rachael B. O'Connor, Nicole H. Moraco, Penelope Lee DeCarolis, Cristina R. Antonescu, Samuel Singer;
Expression profiling of liposarcoma yields a multigene predictor of patient outcome and identifies genes that contribute to liposarcomagenesis.
Cancer Res. 71:2697-2705(2011)

PubMed=21693658; DOI=10.1158/0008-5472.CAN-11-0890; PMCID=PMC3165140
Stacy Ugras, Elliott R. Brill, Anders Jacobsen, Markus Hafner, Nicholas Donald Socci, Penelope Lee DeCarolis, Raya Khanin, Rachael B. O'Connor, Aleksandra Mihailovic, Barry Stephen Taylor, Robert Sheridan ...Show all 18 authors... , Jeffrey Martin Gimble, Agnes J. Viale, Aimee Marie Crago, Cristina R. Antonescu, Chris Sander, Thomas Tuschl, Samuel Singer; Show fewer authors
Small RNA sequencing and functional characterization reveals microRNA-143 tumor suppressor activity in liposarcoma.
Cancer Res. 71:5659-5669(2011)

PubMed=22328974; DOI=10.1158/2159-8290.CD-11-0181; PMCID=PMC3274776
Barry Stephen Taylor, Penelope Lee DeCarolis, Christina V. Angeles, Fabienne Brenet, Nikolaus Schultz, Cristina R. Antonescu, Joseph Michael Scandura, Chris Sander, Agnes J. Viale, Nicholas Donald Socci, Samuel Singer;
Frequent alterations and epigenetic silencing of differentiation pathway genes in structurally rearranged liposarcomas.
Cancer Discov. 1:587-597(2011)

PubMed=22170698; DOI=10.1002/gcc.21917; PMCID=PMC3375024
Yuhsin V. Wu, Tomoyo Okada, Penelope Lee DeCarolis, Nicholas Donald Socci, Rachael B. O'Connor, Rula C. Geha, Chutrudee Joy Somberg, Cristina R. Antonescu, Samuel Singer;
Restoration of C/EBPalpha in dedifferentiated liposarcoma induces G2/M cell cycle arrest and apoptosis.
Genes Chromosomes Cancer 51:313-327(2012)

PubMed=22911243; DOI=10.1155/2012/148614; PMCID=PMC3403520
Eva Wessel Stratford, Russell Castro, Jeanette Daffinrud, Magne Skarn, Silje Lauvrak, Else Munthe, Ola Myklebost;
Characterization of liposarcoma cell lines for preclinical and biological studies.
Sarcoma 2012:148614.1-148614.9(2012)

PubMed=26351324; DOI=10.1158/1535-7163.MCT-15-0074; PMCID=PMC4636476
Beverly A. Teicher, Eric C. Polley, Mark W. Kunkel, David Evans, Thomas E. Silvers, Rene M. Delosh, Julie Laudeman, Chad Ogle, Russell Reinhart, Michael Selby, John Connelly ...Show all 14 authors... , Erik Harris, Anne Monks, Joel Morris; Show fewer authors
Sarcoma cell line screen of oncology drugs and investigational agents identifies patterns associated with gene and microRNA expression.
Mol. Cancer Ther. 14:2452-2462(2015)

PubMed=26643872; DOI=10.18632/oncotarget.6464; PMCID=PMC4767443
Deepika Kanojia, Yasunobu Nagata, Manoj Garg, Dhong Hyun Lee, Aiko Sato, Kenichi Yoshida, Yusuke Sato, Masashi Sanada, Anand Mayakonda, Christoph Bartenhagen, Hans-Ulrich Klein ...Show all 28 authors... , Ngan B. Doan, Jonathan William Said, S. Mohith, Swetha Gunasekar, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Satoru Miyano, Ola Myklebost, Henry He Yang, Martin Dugas, Leonardo Andres Meza-Zepeda, Allan W. Silberman, Charles Forscher, Jeffrey W. Tyner, Seishi Ogawa, Harold Phillip Koeffler; Show fewer authors
Genomic landscape of liposarcoma.
Oncotarget 6:42429-42444(2015)

Cross-references
Cell line databases/resources cancercelllines; CVCL_M823
Cell_Model_Passport; SIDM01796
DepMap; ACH-001799
Encyclopedic resources Wikidata; Q54902989
Gene expression databases GEO; GSM529098
GEO; GSM1228009
GEO; GSM1676337
GEO; GSM1701669
Polymorphism and mutation databases Cosmic; 2800523
Progenetix; CVCL_M823
Entry history
Entry creation05-Nov-2013
Last entry update10-Apr-2025
Version number20