ID   LPS141
AC   CVCL_M823
SY   LS141
DR   cancercelllines; CVCL_M823
DR   Cell_Model_Passport; SIDM01796
DR   Cosmic; 2800523
DR   DepMap; ACH-001799
DR   GEO; GSM529098
DR   GEO; GSM1228009
DR   GEO; GSM1676337
DR   GEO; GSM1701669
DR   Progenetix; CVCL_M823
DR   Wikidata; Q54902989
RX   PubMed=19449367;
RX   PubMed=19706776;
RX   PubMed=20713527;
RX   PubMed=21335544;
RX   PubMed=21693658;
RX   PubMed=22170698;
RX   PubMed=22328974;
RX   PubMed=22911243;
RX   PubMed=26351324;
RX   PubMed=26643872;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   From: Fletcher, Jonathan A.; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School; Boston; USA.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Variations; SNP array analysis.
ST   Source(s): DepMap=ACH-001799
ST   Amelogenin: X
ST   CSF1PO: 11,12
ST   D13S317: 13
ST   D16S539: 12,14
ST   D18S51: 11,14
ST   D21S11: 28,29
ST   D3S1358: 17
ST   D5S818: 12
ST   D7S820: 11,12
ST   D8S1179: 11,13
ST   FGA: 23
ST   Penta D: 9,13
ST   Penta E: 11,12
ST   TH01: 9.3
ST   TPOX: 8,11
ST   vWA: 16,17
DI   NCIt; C3704; Dedifferentiated liposarcoma
DI   ORDO; Orphanet_99970; Dedifferentiated liposarcoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   Age unspecified
CA   Cancer cell line
DT   Created: 05-11-13; Last updated: 10-04-25; Version: 20
//
RX   PubMed=19449367; DOI=10.1002/path.2564;
RA   Snyder E.L., Sandstrom D.J., Law K., Fiore C., Sicinska E.T., Brito J.,
RA   Bailey D., Fletcher J.A., Loda M., Rodig S.J., Dal Cin P.S.,
RA   Fletcher C.D.M.;
RT   "c-Jun amplification and overexpression are oncogenic in liposarcoma
RT   but not always sufficient to inhibit the adipocytic differentiation
RT   programme.";
RL   J. Pathol. 218:292-300(2009).
//
RX   PubMed=19706776; DOI=10.1158/0008-5472.CAN-08-4004; PMCID=PMC2905726;
RA   Muhlenberg T., Zhang Y.-X., Wagner A.J., Grabellus F., Bradner J.E.,
RA   Taeger G., Lang H., Taguchi T., Schuler M., Fletcher J.A., Bauer S.;
RT   "Inhibitors of deacetylases suppress oncogenic KIT signaling,
RT   acetylate HSP90, and induce apoptosis in gastrointestinal stromal
RT   tumors.";
RL   Cancer Res. 69:6941-6950(2009).
//
RX   PubMed=20713527; DOI=10.1158/0008-5472.CAN-10-0745; PMCID=PMC3266950;
RA   Brill E.R., Gobble R.M., Angeles C.V., Lagos-Quintana M., Crago A.M.,
RA   Laxa B.U., DeCarolis P.L., Zhang L., Antonescu C.R., Socci N.D.,
RA   Taylor B.S., Sander C., Koff A., Singer S.;
RT   "ZIC1 overexpression is oncogenic in liposarcoma.";
RL   Cancer Res. 70:6891-6901(2010).
//
RX   PubMed=21335544; DOI=10.1158/0008-5472.CAN-10-3588; PMCID=PMC3070774;
RA   Gobble R.M., Qin L.-X., Brill E.R., Angeles C.V., Ugras S.,
RA   O'Connor R.B., Moraco N.H., DeCarolis P.L., Antonescu C.R., Singer S.;
RT   "Expression profiling of liposarcoma yields a multigene predictor of
RT   patient outcome and identifies genes that contribute to
RT   liposarcomagenesis.";
RL   Cancer Res. 71:2697-2705(2011).
//
RX   PubMed=21693658; DOI=10.1158/0008-5472.CAN-11-0890; PMCID=PMC3165140;
RA   Ugras S., Brill E.R., Jacobsen A., Hafner M., Socci N.D.,
RA   DeCarolis P.L., Khanin R., O'Connor R.B., Mihailovic A., Taylor B.S.,
RA   Sheridan R., Gimble J.M., Viale A.J., Crago A.M., Antonescu C.R.,
RA   Sander C., Tuschl T., Singer S.;
RT   "Small RNA sequencing and functional characterization reveals
RT   microRNA-143 tumor suppressor activity in liposarcoma.";
RL   Cancer Res. 71:5659-5669(2011).
//
RX   PubMed=22170698; DOI=10.1002/gcc.21917; PMCID=PMC3375024;
RA   Wu Y.V., Okada T., DeCarolis P.L., Socci N.D., O'Connor R.B., Geha R.C.,
RA   Somberg C.J., Antonescu C.R., Singer S.;
RT   "Restoration of C/EBPalpha in dedifferentiated liposarcoma induces
RT   G2/M cell cycle arrest and apoptosis.";
RL   Genes Chromosomes Cancer 51:313-327(2012).
//
RX   PubMed=22328974; DOI=10.1158/2159-8290.CD-11-0181; PMCID=PMC3274776;
RA   Taylor B.S., DeCarolis P.L., Angeles C.V., Brenet F., Schultz N.,
RA   Antonescu C.R., Scandura J.M., Sander C., Viale A.J., Socci N.D.,
RA   Singer S.;
RT   "Frequent alterations and epigenetic silencing of differentiation
RT   pathway genes in structurally rearranged liposarcomas.";
RL   Cancer Discov. 1:587-597(2011).
//
RX   PubMed=22911243; DOI=10.1155/2012/148614; PMCID=PMC3403520;
RA   Stratford E.W., Castro R., Daffinrud J., Skarn M., Lauvrak S.,
RA   Munthe E., Myklebost O.;
RT   "Characterization of liposarcoma cell lines for preclinical and
RT   biological studies.";
RL   Sarcoma 2012:148614.1-148614.9(2012).
//
RX   PubMed=26351324; DOI=10.1158/1535-7163.MCT-15-0074; PMCID=PMC4636476;
RA   Teicher B.A., Polley E.C., Kunkel M.W., Evans D., Silvers T.E.,
RA   Delosh R.M., Laudeman J., Ogle C., Reinhart R., Selby M., Connelly J.,
RA   Harris E., Monks A., Morris J.;
RT   "Sarcoma cell line screen of oncology drugs and investigational agents
RT   identifies patterns associated with gene and microRNA expression.";
RL   Mol. Cancer Ther. 14:2452-2462(2015).
//
RX   PubMed=26643872; DOI=10.18632/oncotarget.6464; PMCID=PMC4767443;
RA   Kanojia D., Nagata Y., Garg M., Lee D.H., Sato A., Yoshida K.,
RA   Sato Y., Sanada M., Mayakonda A., Bartenhagen C., Klein H.-U.,
RA   Doan N.B., Said J.W., Mohith S., Gunasekar S., Shiraishi Y., Chiba K.,
RA   Tanaka H., Miyano S., Myklebost O., Yang H.H., Dugas M.,
RA   Meza-Zepeda L.A., Silberman A.W., Forscher C., Tyner J.W., Ogawa S.,
RA   Koeffler H.P.;
RT   "Genomic landscape of liposarcoma.";
RL   Oncotarget 6:42429-42444(2015).
//