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Cellosaurus Rh36 (CVCL_M599)

[Text version]
Cell line name Rh36
Synonyms RH36; RH-36; Birch; BIRCH
Accession CVCL_M599
Resource Identification Initiative To cite this cell line use: Rh36 (RRID:CVCL_M599)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: MD Anderson Cell Lines Project.
Omics: Genomics; Whole exome sequencing.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Proteomics; Subcellular; Cell surface.
Omics: Proteomics; Subcellular; Exosome.
Sequence variations
Disease Embryonal rhabdomyosarcoma (NCIt: C8971)
Embryonal rhabdomyosarcoma (ORDO: Orphanet_99757)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 15Y
Category Cancer cell line
STR profile Source(s): COG

Markers:
AmelogeninX,Y
CSF1PO11,12
D2S133818
D3S135814,16
D5S81813
D7S82010,11
D8S117913
D13S31712,13
D16S53911,13
D18S5116
D19S43314,15
D21S1131,32
FGA25
TH019.3
TPOX8
vWA14,18

Run an STR similarity search on this cell line
Web pages Info; MCLP; -; https://tcpaportal.org/mclp/
Publications

CLPUB00569
Paul S. Dickman, Maria G. Tsokos, Timothy J. Triche;
Biology of rhabdomyosarcoma: cell culture, xenografts, and animal models.
(In book chapter) Rhabdomyosarcoma and related tumors in children and adolescents; Maurer, Harold M. & Ruymann, Frederick Beeman & Pochedly, Carl Eugene (eds.); pp.49-88; CRC Press; Boca Raton; USA (1991)

PubMed=10602515; DOI=10.1038/sj.onc.1203168
Marc F. DeCristofaro, Bryan L. Betz, Wei-Dong Wang, Bernard E. Weissman;
Alteration of hSNF5/INI1/BAF47 detected in rhabdoid cell lines and primary rhabdomyosarcomas but not Wilms' tumors.
Oncogene 18:7559-7565(1999)

PubMed=11051265
Istvan Petak, Leslie Douglas, David M. Tillman, Reka Vernes, Janet A. Houghton;
Pediatric rhabdomyosarcoma cell lines are resistant to Fas-induced apoptosis and highly sensitive to TRAIL-induced apoptosis.
Clin. Cancer Res. 6:4119-4127(2000)

PubMed=12068308; DOI=10.1038/nature00766
Helen R. Davies, Graham Robert Bignell, Charles Cox, Philip J. Stephens, Sarah Edkins, Sheila Clegg, Jon W. Teague, Hayley Woffendin, Mathew J. Garnett, William Bottomley, Neil Davis ...Show all 52 authors... , Ed Dicks, Rebecca Ewing, Yvonne Floyd, Kristian Gray, Sarah Hall, Rachel Hawes, Jaime Hughes, Vivian Kosmidou, Andrew Menzies, Catherine Mould, Adrian Parker, Claire Stevens, Stephen Watt, Steven Hooper, Rebecca Wilson, Hiran Jayatilake, Barry Austin Gusterson, Colin S. Cooper, Janet M. Shipley, Darren Hargrave, Kathy Pritchard-Jones, Norman J. Maitland, Georgia Chenevix-Trench, Gregory J. Riggins, Darell Doty Bigner, Giuseppe Palmieri, Antonio Cossu, Adrienne M. Flanagan, Andrew Nicholson, Judy W.C. Ho, Suet Yi Leung, Siu Tsan Yuen, Barbara L. Weber, Hilliard Foster Seigler, Timothy L. Darrow, Hugh F. Paterson, Richard Marais, Christopher John Marshall, Richard Wooster, Michael Rudolf Stratton, P. Andrew Futreal; Show fewer authors
Mutations of the BRAF gene in human cancer.
Nature 417:949-954(2002)

PubMed=23882450; DOI=10.3389/fonc.2013.00183; PMCID=PMC3713458
Ashley R.P. Hinson, Rosanne Jones, Lisa E.S. Crose, Brian C. Belyea, Frederic G. Barr, Corinne Mary Linardic;
Human rhabdomyosarcoma cell lines for rhabdomyosarcoma research: utility and pitfalls.
Front. Oncol. 3:183.1-183.12(2013)

PubMed=26351324; DOI=10.1158/1535-7163.MCT-15-0074; PMCID=PMC4636476
Beverly A. Teicher, Eric C. Polley, Mark W. Kunkel, David Evans, Thomas E. Silvers, Rene M. Delosh, Julie Laudeman, Chad Ogle, Russell Reinhart, Michael Selby, John Connelly ...Show all 14 authors... , Erik Harris, Anne Monks, Joel Morris; Show fewer authors
Sarcoma cell line screen of oncology drugs and investigational agents identifies patterns associated with gene and microRNA expression.
Mol. Cancer Ther. 14:2452-2462(2015)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076
Jun Li, Wei Zhao, Rehan Akbani, Wen-Bin Liu, Zhen-Lin Ju, Shi-Yun Ling, Christopher P. Vellano, Paul Roebuck, Qing-Hua Yu, A. Karina Eterovic, Lauren Averett Byers ...Show all 25 authors... , Michael A. Davies, Wan-Leng Deng, Y.N. Vashisht Gopal, Guo Chen, Erika Maria von Euw, Dennis Joseph Slamon, Dylan Conklin, John Victor Heymach, Adi F. Gazdar, John D. Minna, Jeffrey N. Myers, Yi-Ling Lu, Gordon B. Mills, Han Liang; Show fewer authors
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=31448612; DOI=10.1021/acs.jproteome.9b00157
Ghina Rammal, Assil Fahs, Firas H. Kobeissy, Yehia Mechref, Jing-Fu Zhao, Rui Zhu, Mona Diab-Assaf, Raya Saab, Sandra E. Ghayad;
Proteomic profiling of rhabdomyosarcoma-derived exosomes yield insights into their functional role in paracrine signaling.
J. Proteome Res. 18:3567-3579(2019)

PubMed=36768928; DOI=10.3390/ijms24032601; PMCID=PMC9917031
Andrea Timpanaro, Caroline Piccand, Anne-Christine Uldry, Peter-Karl Bode, Dzhangar Dzhumashev, Rita Sala, Manfred Heller, Jochen Rossler, Michele Bernasconi;
Surfaceome profiling of cell lines and patient-derived xenografts confirm FGFR4, NCAM1, CD276, and highlight AGRL2, JAM3, and L1CAM as surface targets for rhabdomyosarcoma.
Int. J. Mol. Sci. 24:2601.1-2601.28(2023)

Cross-references
Cell line databases/resources cancercelllines; CVCL_M599
Cell_Model_Passport; SIDM01350
DepMap; ACH-001751
Encyclopedic resources Wikidata; Q54950343
Gene expression databases GEO; GSM186453
GEO; GSM186454
GEO; GSM1676312
GEO; GSM1701646
Polymorphism and mutation databases Cosmic; 724814
Cosmic; 802042
Progenetix; CVCL_M599
Proteomic databases PRIDE; PXD007755
PRIDE; PXD039480
Entry history
Entry creation05-Nov-2013
Last entry update10-Apr-2025
Version number24