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Cellosaurus publication CLPUB00569

Publication number CLPUB00569
Authors Dickman P.S., Tsokos M., Triche T.J.
Title Biology of rhabdomyosarcoma: cell culture, xenografts, and animal models.
Citation (In) Rhabdomyosarcoma and related tumors in children and adolescents; Maurer H.M., Ruymann F.B., Pochedly C.E. (eds); pp.49-88; CRC Press; Boca Raton (1991)
Abstract Experimental models of human neoplasms have provided valuable tools for exploring numerous biological and clinical features of tumors. Rhabdomyosarcoma (RMS) has been studied using tumors induced in experimental animals, in cell lines derived from such tumors, in cell lines developed from human tumors, and in xenografts in athymic or nude mice using both human primary tumors and tumor cell lines. In this chapter the authors will describe these models, and information derived from the various tumor systems will be reviewed. Special emphasis is placed on biological and molecular biological findings, as well as using clinical or therapeutic relevance of studies of human cell lines and xenografts.
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