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Cellosaurus STHdhQ111 (CVCL_M591)

[Text version]
Cell line name STHdhQ111
Synonyms STHdh(Q111); STHdhQ111/Q111; Q111; ST HDH Q111/111; CHDI-90000071; CH00095
Accession CVCL_M591
Resource Identification Initiative To cite this cell line use: STHdhQ111 (RRID:CVCL_M591)
Comments Characteristics: From a transgenic mouse containing homozygous HTT loci with a humanized exon 1 containing 111 polyglutamine repeats (Coriell=CH00095).
Genetic integration: Method=Transduction; Gene=UniProtKB; P03070; SV40 large T antigen.
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) (Note=tsA58).
Derived from site: In situ; Embryonic brain, forebrain, striatum; UBERON=UBERON_0006240+UBERON_0002435.
Cell type: Neuron; CL=CL_0000540.
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Age at sampling 14FD
Category Transformed cell line
Publications

PubMed=11092756; DOI=10.1093/hmg/9.19.2799
Trettel F., Rigamonti D., Hilditch-Maguire P., Wheeler V.C., Sharp A.H., Persichetti F., Cattaneo E., MacDonald M.E.
Dominant phenotypes produced by the HD mutation in STHdh(Q111) striatal cells.
Hum. Mol. Genet. 9:2799-2809(2000)

PubMed=21985783; DOI=10.1172/JCI57552; PMCID=PMC3223861
Keryer G., Pineda J.R., Liot G., Kim J., Dietrich P., Benstaali C., Smith K., Cordelieres F.P., Spassky N., Ferrante R.J., Dragatsis I., Saudou F.
Ciliogenesis is regulated by a huntingtin-HAP1-PCM1 pathway and is altered in Huntington disease.
J. Clin. Invest. 121:4372-4382(2011)

PubMed=30256717; DOI=10.1091/mbc.E18-09-0590; PMCID=PMC6249865
Hung C.L.-K., Maiuri T., Bowie L.E., Gotesman R., Son S., Falcone M., Giordano J.V., Gillis T., Mattis V.B., Lau T., Kwan V., Wheeler V.C., Schertzer J., Singh K., Truant R.
A patient-derived cellular model for Huntington's disease reveals phenotypes at clinically relevant CAG lengths.
Mol. Biol. Cell 29:2809-2820(2018)

Cross-references
Cell line collections (Providers) Coriell; CH00095
Encyclopedic resources Wikidata; Q54970579
Entry history
Entry creation05-Nov-2013
Last entry update10-Sep-2024
Version number13