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Cellosaurus STHdhQ111 (CVCL_M591)

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Cell line name STHdhQ111
Synonyms STHdh(Q111); STHdhQ111/Q111; Q111; ST HDH Q111/111; CHDI-90000071; CH00095
Accession CVCL_M591
Resource Identification Initiative To cite this cell line use: STHdhQ111 (RRID:CVCL_M591)
Comments Characteristics: From a transgenic mouse containing homozygous HTT loci with a humanized exon 1 containing 111 polyglutamine repeats (Coriell=CH00095).
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Genetic integration: Method=Transduction; Gene=UniProtKB; P03070; Simian virus 40 (SV40) large T antigen.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) (Note=tsA58).
Derived from site: In situ; Embryonic brain, forebrain, striatum; UBERON=UBERON_0006240+UBERON_0002435.
Cell type: Neuron; CL=CL_0000540.
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Age at sampling 14FD
Category Transformed cell line
Publications

PubMed=11092756; DOI=10.1093/hmg/9.19.2799
Flavia Trettel, Dorotea Rigamonti, Paige Hilditch-Maguire, Vanessa Chantal Wheeler, Alan H. Sharp, Francesca Persichetti, Elena Cattaneo, Marcy Elizabeth MacDonald;
Dominant phenotypes produced by the HD mutation in STHdh(Q111) striatal cells.
Hum. Mol. Genet. 9:2799-2809(2000)

PubMed=21985783; DOI=10.1172/JCI57552; PMCID=PMC3223861
Guy Keryer, Jose R. Pineda, Geraldine Liot, Jinho Kim, Paula Dietrich, Caroline Benstaali, Karen Smith, Fabrice P. Cordelieres, Nathalie Spassky, Robert J. Ferrante, Ioannis Dragatsis, Frederic Saudou;
Ciliogenesis is regulated by a huntingtin-HAP1-PCM1 pathway and is altered in Huntington disease.
J. Clin. Invest. 121:4372-4382(2011)

PubMed=30256717; DOI=10.1091/mbc.E18-09-0590; PMCID=PMC6249865
Claudia Lin-Kar Hung, Tamara Maiuri, Laura Erin Bowie, Ryan Gotesman, Susie Son, Mina Falcone, James Victor Giordano, Tammy Gillis, Virginia B. Mattis, Trevor Lau, Vickie Kwan ...Show all 15 authors... , Vanessa Chantal Wheeler, Jonathan Schertzer, Karun Singh, Ray Truant; Show fewer authors
A patient-derived cellular model for Huntington's disease reveals phenotypes at clinically relevant CAG lengths.
Mol. Biol. Cell 29:2809-2820(2018)

Cross-references
Cell line collections (Providers) Coriell; CH00095
Encyclopedic resources Wikidata; Q54970579
Entry history
Entry creation05-Nov-2013
Last entry update14-Aug-2025
Version number14