ID   STHdhQ111
AC   CVCL_M591
SY   STHdh(Q111); STHdhQ111/Q111; Q111; ST HDH Q111/111; CHDI-90000071; CH00095
DR   Coriell; CH00095
DR   Wikidata; Q54970579
RX   PubMed=11092756;
RX   PubMed=21985783;
RX   PubMed=30256717;
CC   Characteristics: From a transgenic mouse containing homozygous HTT loci with a humanized exon 1 containing 111 polyglutamine repeats (Coriell=CH00095).
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P03070; SV40 large T antigen.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
CC   Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) (Note=tsA58).
CC   Derived from site: In situ; Embryonic brain, forebrain, striatum; UBERON=UBERON_0006240+UBERON_0002435.
CC   Cell type: Neuron; CL=CL_0000540.
OX   NCBI_TaxID=10090; ! Mus musculus (Mouse)
AG   14FD
CA   Transformed cell line
DT   Created: 05-11-13; Last updated: 10-09-24; Version: 13
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RX   PubMed=11092756; DOI=10.1093/hmg/9.19.2799;
RA   Trettel F., Rigamonti D., Hilditch-Maguire P., Wheeler V.C.,
RA   Sharp A.H., Persichetti F., Cattaneo E., MacDonald M.E.;
RT   "Dominant phenotypes produced by the HD mutation in STHdh(Q111)
RT   striatal cells.";
RL   Hum. Mol. Genet. 9:2799-2809(2000).
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RX   PubMed=21985783; DOI=10.1172/JCI57552; PMCID=PMC3223861;
RA   Keryer G., Pineda J.R., Liot G., Kim J., Dietrich P., Benstaali C.,
RA   Smith K., Cordelieres F.P., Spassky N., Ferrante R.J., Dragatsis I.,
RA   Saudou F.;
RT   "Ciliogenesis is regulated by a huntingtin-HAP1-PCM1 pathway and is
RT   altered in Huntington disease.";
RL   J. Clin. Invest. 121:4372-4382(2011).
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RX   PubMed=30256717; DOI=10.1091/mbc.E18-09-0590; PMCID=PMC6249865;
RA   Hung C.L.-K., Maiuri T., Bowie L.E., Gotesman R., Son S., Falcone M.,
RA   Giordano J.V., Gillis T., Mattis V.B., Lau T., Kwan V., Wheeler V.C.,
RA   Schertzer J., Singh K., Truant R.;
RT   "A patient-derived cellular model for Huntington's disease reveals
RT   phenotypes at clinically relevant CAG lengths.";
RL   Mol. Biol. Cell 29:2809-2820(2018).
//