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Cellosaurus ALMC-2 (CVCL_M526)

[Text version]
Cell line name ALMC-2
Synonyms ALMC2
Accession CVCL_M526
Resource Identification Initiative To cite this cell line use: ALMC-2 (RRID:CVCL_M526)
Comments Characteristics: Produces IgG lambda.
Omics: Transcriptomics; RNAseq.
Omics: Variations; Array-based CGH.
Donor information: Established from a patient suffering from primary systemic amyloidosis which relapsed with multiple myeloma.
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Cell type: Plasma cell; CL=CL_0000786.
Disease Plasma cell myeloma (NCIt: C3242)
Multiple myeloma (ORDO: Orphanet_29073)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_M525 ! ALMC-1
Sex of cell Female
Age at sampling 50Y
Category Cancer cell line
Web pages Info; Keats Lab; -; https://www.keatslab.org/myeloma-cell-lines
Publications

DOI=10.1182/blood.V112.11.2732.2732
Jonathan J. Keats, Bonnie K. Arendt, Esteban Braggio, Michael T. Barrett, Tammy L. Price-Troska, Rafael Fonseca, Peter Leif Bergsagel, Diane F. Jelinek;
Comparison of multiple myeloma donor patient samples and derived cell lines identifies a confirmed hyperdiploid myeloma cell line and demonstrates remarkable genetic similarity between cell lines and patient samples.
Blood 112 Suppl. 1:2732a-2732a(2008)

PubMed=18567838; DOI=10.1182/blood-2008-03-143040; PMCID=PMC2518895
Bonnie K. Arendt, Marina Ramirez-Alvarado, Laura A. Sikkink, Jonathan J. Keats, Gregory J. Ahmann, Angela Dispenzieri, Rafael Fonseca, Rhett P. Ketterling, Ryan A. Knudson, Erin M. Mulvihill, Renee C. Tschumper ...Show all 14 authors... , Xiao-Sheng Wu, Steven R. Zeldenrust, Diane F. Jelinek; Show fewer authors
Biologic and genetic characterization of the novel amyloidogenic lambda light chain-secreting human cell lines, ALMC-1 and ALMC-2.
Blood 112:1931-1941(2008)

PubMed=23992230; DOI=10.1111/ejh.12192; PMCID=PMC3834223
Alexandra J. Greenberg, Denise K. Walters, Shaji K. Kumar, S. Vincent Rajkumar, Diane F. Jelinek;
Responsiveness of cytogenetically discrete human myeloma cell lines to lenalidomide: lack of correlation with cereblon and interferon regulatory factor 4 expression levels.
Eur. J. Haematol. 91:504-513(2013)

PubMed=24013424; DOI=10.4161/cc.26193; PMCID=PMC3865013
Denise K. Walters, Bonnie K. Arendt, Diane F. Jelinek;
CD147 regulates the expression of MCT1 and lactate export in multiple myeloma cells.
Cell Cycle 12:3175-3183(2013)

PubMed=25015330; DOI=10.18632/oncotarget.2159; PMCID=PMC4170605
Bonnie K. Arendt, Denise K. Walters, Xiao Wu, Renee C. Tschumper, Diane F. Jelinek;
Multiple myeloma cell-derived microvesicles are enriched in CD147 expression and enhance tumor cell proliferation.
Oncotarget 5:5686-5699(2014)

CLPUB00604
Sharon Chow;
Targeted capture and sequencing of immunoglobulin rearrangements in multiple myeloma to enable detection of minimal residual disease.
Thesis MSc (2017); University of Toronto; Toronto; Canada

PubMed=32123307; DOI=10.1038/s41375-020-0785-1; PMCID=PMC7483300
Vishesh Sarin, Katharine Yu, Ian D. Ferguson, Olivia Gugliemini, Matthew A. Nix, Byron Hann, Marina Sirota, Arun P. Wiita;
Evaluating the efficacy of multiple myeloma cell lines as models for patient tumors via transcriptomic correlation analysis.
Leukemia 34:2754-2765(2020)

Cross-references
Encyclopedic resources Wikidata; Q54749244
Entry history
Entry creation05-Nov-2013
Last entry update14-Aug-2025
Version number17