Cellosaurus logo
expasy logo

Cellosaurus ALMC-1 (CVCL_M525)

[Text version]
Cell line name ALMC-1
Synonyms ALMC1
Accession CVCL_M525
Resource Identification Initiative To cite this cell line use: ALMC-1 (RRID:CVCL_M525)
Comments Characteristics: Produces IgG lambda.
Omics: Array-based CGH.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Donor information: Established from a patient suffering from primary systemic amyloidosis which relapsed with multiple myeloma.
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Disease Plasma cell myeloma (NCIt: C3242)
Multiple myeloma (ORDO: Orphanet_29073)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_M526 ! ALMC-2
Sex of cell Female
Age at sampling 50Y
Category Cancer cell line
Web pages https://www.keatslab.org/myeloma-cell-lines/hmcl-characteristics
Publications

DOI=10.1182/blood.V112.11.2732.2732
Keats J.J., Arendt B.K., Braggio E., Barrett M.T., Price-Troska T.L., Fonseca R., Bergsagel P.L., Jelinek D.F.
Comparison of multiple myeloma donor patient samples and derived cell lines identifies a confirmed hyperdiploid myeloma cell line and demonstrates remarkable genetic similarity between cell lines and patient samples.
Blood 112 Suppl. 1:2732a-2732a(2008)

PubMed=18567838; DOI=10.1182/blood-2008-03-143040
Arendt B.K., Ramirez-Alvarado M., Sikkink L.A., Keats J.J., Ahmann G.J., Dispenzieri A., Fonseca R., Ketterling R.P., Knudson R.A., Mulvihill E.M., Tschumper R.C., Wu X.-S., Zeldenrust S.R., Jelinek D.F.
Biologic and genetic characterization of the novel amyloidogenic lambda light chain-secreting human cell lines, ALMC-1 and ALMC-2.
Blood 112:1931-1941(2008)

PubMed=23992230; DOI=10.1111/ejh.12192
Greenberg A.J., Walters D.K., Kumar S.K., Rajkumar S.V., Jelinek D.F.
Responsiveness of cytogenetically discrete human myeloma cell lines to lenalidomide: lack of correlation with cereblon and interferon regulatory factor 4 expression levels.
Eur. J. Haematol. 91:504-513(2013)

PubMed=24013424; DOI=10.4161/cc.26193
Walters D.K., Arendt B.K., Jelinek D.F.
CD147 regulates the expression of MCT1 and lactate export in multiple myeloma cells.
Cell Cycle 12:3175-3183(2013)

CLPUB00604
Chow S.
Targeted capture and sequencing of immunoglobulin rearrangements in multiple myeloma to enable detection of minimal residual disease.
Thesis MSc (2017), University of Toronto, Canada

PubMed=32123307; DOI=10.1038/s41375-020-0785-1
Sarin V., Yu K., Ferguson I.D., Gugliemini O., Nix M.A., Hann B., Sirota M., Wiita A.P.
Evaluating the efficacy of multiple myeloma cell lines as models for patient tumors via transcriptomic correlation analysis.
Leukemia 34:2754-2765(2020)

Cross-references
Encyclopedic resources Wikidata; Q54749243
Gene expression databases GEO; GSE54507
Entry history
Entry creation05-Nov-2013
Last entry update29-Jun-2023
Version number14