Cellosaurus logo
expasy logo

Cellosaurus MT-1 [Human leukemia] (CVCL_M518)

[Text version]
Cell line name MT-1 [Human leukemia]
Synonyms FCCH1043
Accession CVCL_M518
Resource Identification Initiative To cite this cell line use: MT-1 [Human leukemia] (RRID:CVCL_M518)
Comments Population: Japanese.
Characteristics: Was established by co-cultivation of cells from a 69 year old male T-cell leukemia patient with cord leukocytes from a female infant (CelloPub=CLPUB00542).
Virology: HTLV-1 producing cell line.
Doubling time: 48-54 hours (PubMed=6966589).
Transformant: NCBI_TaxID; 11908; Human T-lymphotropic virus 1 (HTLV-1).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
Disease Adult T-cell leukemia/lymphoma (NCIt: C3184)
Adult T-cell leukemia/lymphoma (ORDO: Orphanet_86875)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 69Y
Category Cancer cell line
STR profile Source(s): JCRB=JCRB1209

Markers:
AmelogeninX,Y
CSF1PO11,13
D5S81810,12
D7S82011,13
D13S3178
D16S5399
TH018,9
TPOX8,9
vWA17,18

Run an STR similarity search on this cell line
Publications

PubMed=6966589; DOI=10.20772/cancersci1959.71.1_155
Isao Miyoshi, Ichiro Kubonishi, Mitsuo Sumida, Shunkichi Hiraki, Teruhiko Tsubota, Ikuro Kimura, Kanji Miyamoto, Jiro Sato;
A novel T-cell line derived from adult T-cell leukemia.
Gann 71:155-156(1980)

PubMed=6275274; DOI=10.1038/294770a0
Isao Miyoshi, Ichiro Kubonishi, Shizuo Yoshimoto, Tadaatsu Akagi, Yuji Ohtsuki, Yukimasa Shiraishi, Kinya Nagata, Yorio Hinuma;
Type C virus particles in a cord T-cell line derived by co-cultivating normal human cord leukocytes and human leukaemic T cells.
Nature 294:770-771(1981)

PubMed=7031654; DOI=10.1073/pnas.78.10.6476; PMCID=PMC349062
Yorio Hinuma, Kinya Nagata, Masao Hanaoka, Masuyo Nakai, Tadashi Matsumoto, Ken-ichiro Kinoshita, Shigeru Shirakawa, Isao Miyoshi;
Adult T-cell leukemia: antigen in an ATL cell line and detection of antibodies to the antigen in human sera.
Proc. Natl. Acad. Sci. U.S.A. 78:6476-6480(1981)

CLPUB00542
Isao Miyoshi, Hirokuni Taguchi, Ichiro Kubonishi, Shizuo Yoshimoto, Yuji Ohtsuki, Yukimasa Shiraishi, Tadaatsu Akagi;
Type C virus-producing cell lines derived from adult T cell leukemia.
Gann Monogr. Cancer Res. 28:219-228(1982)

PubMed=6327813; DOI=10.4049/jimmunol.132.6.3005
Yuji Wano, Takashi Uchiyama, Kiyoshi Fukui, Michiyuki Maeda, Haruto Uchino, Junji Yodoi;
Characterization of human interleukin 2 receptor (Tac antigen) in normal and leukemic T cells: co-expression of normal and aberrant receptors on Hut-102 cells.
J. Immunol. 132:3005-3010(1984)

PubMed=2985879; DOI=10.1016/0145-2126(85)90084-0
Hans Gunther Drexler, Gerhard Gaedicke, Jun Minowada;
Isoenzyme studies in human leukemia-lymphoma cell lines -- 1 Carboxylic esterase.
Leuk. Res. 9:209-229(1985)

PubMed=3001699; DOI=10.1073/pnas.82.24.8359; PMCID=PMC390915
Tetsuyuki Kiyokawa, Motoharu Seiki, Shintaro Iwashita, Kenichi Imagawa, Fumio Shimizu, Mitsuaki Yoshida;
p27x-III and p21x-III, proteins encoded by the pX sequence of human T-cell leukemia virus type I.
Proc. Natl. Acad. Sci. U.S.A. 82:8359-8363(1985)

PubMed=3159941; DOI=10.1016/0145-2126(85)90134-1
Hans Gunther Drexler, Gerhard Gaedicke, Jun Minowada;
Isoenzyme studies in human leukemia-lymphoma cell lines -- III Beta-hexosaminidase (E.C. 3.2.1.30).
Leuk. Res. 9:549-559(1985)

PubMed=3874327; DOI=10.1016/0145-2126(85)90133-x
Hans Gunther Drexler, Gerhard Gaedicke, Jun Minowada;
Isoenzyme studies in human leukemia-lymphoma cells lines -- II. Acid phosphatase.
Leuk. Res. 9:537-548(1985)

PubMed=1765142; DOI=10.1016/0014-5793(91)81402-t
Satoshi Orita, Akihiko Saiga, Shin Takagi, Tatsuro Tanaka, Koichi Okumura, Yuko Aono, Yorio Hinuma, Hisanaga Igarashi;
A novel alternatively spliced viral mRNA transcribed in cells infected with human T cell leukemia virus type 1 is mainly responsible for expressing p21X protein.
FEBS Lett. 295:127-134(1991)

PubMed=7662981; DOI=10.1182/blood.V86.6.2350.bloodjournal8662350
Kazunori Imada, Akifumi Takaori-Kondo, Tsuyoshi Akagi, Kunitada Shimotohno, Kazuo Sugamura, Toshio Hattori, Hirohiko Yamabe, Minoru Okuma, Takashi Uchiyama;
Tumorigenicity of human T-cell leukemia virus type I-infected cell lines in severe combined immunodeficient mice and characterization of the cells proliferating in vivo.
Blood 86:2350-2357(1995)

PubMed=8957066; DOI=10.1111/j.1349-7006.1996.tb03112.x; PMCID=PMC5920998
Nobuhiro Kawasaki, Yoshinobu Matsuo, Tadashi Yoshino, Hiroyuki Yanai, Takashi Oka, Norihiro Teramoto, Cao Liu, Eisaku Kondo, Jun Minowada, Tadaatsu Akagi;
Metastatic potential of lymphoma/leukemia cell lines in SCID mice is closely related to expression of CD44.
Jpn. J. Cancer Res. 87:1070-1077(1996)

PubMed=15638862; DOI=10.1111/j.1365-2141.2004.05289.x
Hiroo Hasegawa, Yasuaki Yamada, Hitomi Harasawa, Tomohiro Tsuji, Ken Murata, Kazuyuki Sugahara, Kazuto Tsuruda, Shuichi Ikeda, Yoshitaka Imaizumi, Masao Tomonaga, Masoto Masuda ...Show all 13 authors... , Nobuyuki Takasu, Shimeru Kamihira; Show fewer authors
Sensitivity of adult T-cell leukaemia lymphoma cells to tumour necrosis factor-related apoptosis-inducing ligand.
Br. J. Haematol. 128:253-265(2005)

PubMed=17170727; DOI=10.1038/sj.leu.2404486
Yorick Sandberg, Brenda Verhaaf, Ellen J. van Gastel-Mol, Ingrid L.M. Wolvers-Tettero, John De Vos, Roderick A.F. MacLeod, Jeroen G. Noordzij, Willem A. Dik, Jack J.M. van Dongen, Anton W. Langerak;
Human T-cell lines with well-defined T-cell receptor gene rearrangements as controls for the BIOMED-2 multiplex polymerase chain reaction tubes.
Leukemia 21:230-237(2007)

PubMed=19220422; DOI=10.1111/j.1600-0609.2009.01211.x
Shimeru Kamihira, Chiharu Terada, Daisuke Sasaki, Katsunori Yanagihara, Kunihiro Tsukasaki, Hiroo Hasegawa, Yasuaki Yamada;
Aberrant p53 protein expression and function in a panel of hematopoietic cell lines with different p53 mutations.
Eur. J. Haematol. 82:301-307(2009)

PubMed=19710698; DOI=10.1038/leu.2009.171
Hiroo Hasegawa, Yasuaki Yamada, Hidekatsu Iha, Kunihiro Tsukasaki, K. Nagai, Sunao Atogami, K. Sugahara, Kazuto Tsuruda, Akiko Ishizaki, Shimeru Kamihira;
Activation of p53 by Nutlin-3a, an antagonist of MDM2, induces apoptosis and cellular senescence in adult T-cell leukemia cells.
Leukemia 23:2090-2101(2009)

PubMed=29892436; DOI=10.1098/rsos.172472; PMCID=PMC5990783
Setsuko Shioda, Fumio Kasai, Ken Watanabe, Kohei Kawakami, Azusa Ohtani, Masashi Iemura, Midori Ozawa, Akemi Arakawa, Noriko Hirayama, Eiko Kawaguchi, Tomoko Tano ...Show all 15 authors... , Sayaka Miyata, Motonobu Satoh, Norio Shimizu, Arihiro Kohara; Show fewer authors
Screening for 15 pathogenic viruses in human cell lines registered at the JCRB Cell Bank: characterization of in vitro human cells by viral infection.
R. Soc. Open Sci. 5:172472-172472(2018)

Cross-references
Cell line collections (Providers) JCRB; JCRB0063 - Discontinued
JCRB; JCRB1209
JCRB; NIHS0526 - Discontinued
Cell line databases/resources cancercelllines; CVCL_M518
Biological sample resources BioSample; SAMN03472436
Encyclopedic resources Wikidata; Q54906928
Polymorphism and mutation databases IARC_TP53; 27001
Entry history
Entry creation05-Nov-2013
Last entry update14-Aug-2025
Version number27