ID   MT-1 [Human leukemia]
AC   CVCL_M518
SY   FCCH1043
DR   BioSample; SAMN03472436
DR   cancercelllines; CVCL_M518
DR   IARC_TP53; 27001
DR   JCRB; JCRB0063
DR   JCRB; JCRB1209
DR   JCRB; NIHS0526
DR   Wikidata; Q54906928
RX   CelloPub=CLPUB00542;
RX   PubMed=1765142;
RX   PubMed=2985879;
RX   PubMed=3001699;
RX   PubMed=3159941;
RX   PubMed=3874327;
RX   PubMed=6275274;
RX   PubMed=6966589;
RX   PubMed=7031654;
RX   PubMed=7662981;
RX   PubMed=8957066;
RX   PubMed=15638862;
RX   PubMed=17170727;
RX   PubMed=19220422;
RX   PubMed=19710698;
RX   PubMed=29892436;
CC   Population: Japanese.
CC   Characteristics: Was established by co-cultivation of cells from a 69 year old male T-cell leukemia patient with cord leukocytes from a female infant (CelloPub=CLPUB00542).
CC   Virology: HTLV-1 producing cell line.
CC   Doubling time: 48-54 hours (PubMed=6966589).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Cys176Tyr (c.527G>A); ClinVar=VCV000186451; Zygosity=Unspecified (PubMed=19220422; PubMed=19710698).
CC   Transformant: NCBI_TaxID; 11908; Human T-lymphotropic virus 1 (HTLV-1).
CC   Discontinued: JCRB; JCRB0063; probable.
CC   Discontinued: JCRB; NIHS0526; true.
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
CC   Cell type: T-cell; CL=CL_0000084.
ST   Source(s): JCRB=JCRB1209
ST   Amelogenin: X,Y
ST   CSF1PO: 11,13
ST   D13S317: 8
ST   D16S539: 9
ST   D5S818: 10,12
ST   D7S820: 11,13
ST   TH01: 8,9
ST   TPOX: 8,9
ST   vWA: 17,18
DI   NCIt; C3184; Adult T-cell leukemia/lymphoma
DI   ORDO; Orphanet_86875; Adult T-cell leukemia/lymphoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   69Y
CA   Cancer cell line
DT   Created: 05-11-13; Last updated: 19-12-24; Version: 26
//
RX   CelloPub=CLPUB00542;
RA   Miyoshi I., Taguchi H., Kubonishi I., Yoshimoto S., Ohtsuki Y.,
RA   Shiraishi Y., Akagi T.;
RT   "Type C virus-producing cell lines derived from adult T cell leukemia.";
RL   Gann Monogr. Cancer Res. 28:219-228(1982).
//
RX   PubMed=1765142; DOI=10.1016/0014-5793(91)81402-t;
RA   Orita S., Saiga A., Takagi S., Tanaka T., Okumura K., Aono Y.,
RA   Hinuma Y., Igarashi H.;
RT   "A novel alternatively spliced viral mRNA transcribed in cells
RT   infected with human T cell leukemia virus type 1 is mainly responsible
RT   for expressing p21X protein.";
RL   FEBS Lett. 295:127-134(1991).
//
RX   PubMed=2985879; DOI=10.1016/0145-2126(85)90084-0;
RA   Drexler H.G., Gaedicke G., Minowada J.;
RT   "Isoenzyme studies in human leukemia-lymphoma cell lines -- 1.
RT   Carboxylic esterase.";
RL   Leuk. Res. 9:209-229(1985).
//
RX   PubMed=3001699; DOI=10.1073/pnas.82.24.8359; PMCID=PMC390915;
RA   Kiyokawa T., Seiki M., Iwashita S., Imagawa K., Shimizu F.,
RA   Yoshida M.;
RT   "p27x-III and p21x-III, proteins encoded by the pX sequence of human
RT   T-cell leukemia virus type I.";
RL   Proc. Natl. Acad. Sci. U.S.A. 82:8359-8363(1985).
//
RX   PubMed=3159941; DOI=10.1016/0145-2126(85)90134-1;
RA   Drexler H.G., Gaedicke G., Minowada J.;
RT   "Isoenzyme studies in human leukemia-lymphoma cell lines -- III.
RT   Beta-hexosaminidase (E.C. 3.2.1.30).";
RL   Leuk. Res. 9:549-559(1985).
//
RX   PubMed=3874327; DOI=10.1016/0145-2126(85)90133-x;
RA   Drexler H.G., Gaedicke G., Minowada J.;
RT   "Isoenzyme studies in human leukemia-lymphoma cells lines -- II. Acid
RT   phosphatase.";
RL   Leuk. Res. 9:537-548(1985).
//
RX   PubMed=6275274; DOI=10.1038/294770a0;
RA   Miyoshi I., Kubonishi I., Yoshimoto S., Akagi T., Ohtsuki Y.,
RA   Shiraishi Y., Nagata K., Hinuma Y.;
RT   "Type C virus particles in a cord T-cell line derived by co-cultivating
RT   normal human cord leukocytes and human leukaemic T cells.";
RL   Nature 294:770-771(1981).
//
RX   PubMed=6966589; DOI=10.20772/cancersci1959.71.1_155;
RA   Miyoshi I., Kubonishi I., Sumida M., Hiraki S., Tsubota T., Kimura I.,
RA   Miyamoto K., Sato J.;
RT   "A novel T-cell line derived from adult T-cell leukemia.";
RL   Gann 71:155-156(1980).
//
RX   PubMed=7031654; DOI=10.1073/pnas.78.10.6476; PMCID=PMC349062;
RA   Hinuma Y., Nagata K., Hanaoka M., Nakai M., Matsumoto T.,
RA   Kinoshita K.-i., Shirakawa S., Miyoshi I.;
RT   "Adult T-cell leukemia: antigen in an ATL cell line and detection of
RT   antibodies to the antigen in human sera.";
RL   Proc. Natl. Acad. Sci. U.S.A. 78:6476-6480(1981).
//
RX   PubMed=7662981; DOI=10.1182/blood.V86.6.2350.bloodjournal8662350;
RA   Imada K., Takaori-Kondo A., Akagi T., Shimotohno K., Sugamura K.,
RA   Hattori T., Yamabe H., Okuma M., Uchiyama T.;
RT   "Tumorigenicity of human T-cell leukemia virus type I-infected cell
RT   lines in severe combined immunodeficient mice and characterization of
RT   the cells proliferating in vivo.";
RL   Blood 86:2350-2357(1995).
//
RX   PubMed=8957066; DOI=10.1111/j.1349-7006.1996.tb03112.x; PMCID=PMC5920998;
RA   Kawasaki N., Matsuo Y., Yoshino T., Yanai H., Oka T., Teramoto N.,
RA   Liu C., Kondo E., Minowada J., Akagi T.;
RT   "Metastatic potential of lymphoma/leukemia cell lines in SCID mice is
RT   closely related to expression of CD44.";
RL   Jpn. J. Cancer Res. 87:1070-1077(1996).
//
RX   PubMed=15638862; DOI=10.1111/j.1365-2141.2004.05289.x;
RA   Hasegawa H., Yamada Y., Harasawa H., Tsuji T., Murata K., Sugahara K.,
RA   Tsuruda K., Ikeda S., Imaizumi Y., Tomonaga M., Masuda M., Takasu N.,
RA   Kamihira S.;
RT   "Sensitivity of adult T-cell leukaemia lymphoma cells to tumour
RT   necrosis factor-related apoptosis-inducing ligand.";
RL   Br. J. Haematol. 128:253-265(2005).
//
RX   PubMed=17170727; DOI=10.1038/sj.leu.2404486;
RA   Sandberg Y., Verhaaf B., van Gastel-Mol E.J., Wolvers-Tettero I.L.M.,
RA   De Vos J., MacLeod R.A.F., Noordzij J.G., Dik W.A., van Dongen J.J.M.,
RA   Langerak A.W.;
RT   "Human T-cell lines with well-defined T-cell receptor gene
RT   rearrangements as controls for the BIOMED-2 multiplex polymerase chain
RT   reaction tubes.";
RL   Leukemia 21:230-237(2007).
//
RX   PubMed=19220422; DOI=10.1111/j.1600-0609.2009.01211.x;
RA   Kamihira S., Terada C., Sasaki D., Yanagihara K., Tsukasaki K.,
RA   Hasegawa H., Yamada Y.;
RT   "Aberrant p53 protein expression and function in a panel of
RT   hematopoietic cell lines with different p53 mutations.";
RL   Eur. J. Haematol. 82:301-307(2009).
//
RX   PubMed=19710698; DOI=10.1038/leu.2009.171;
RA   Hasegawa H., Yamada Y., Iha H., Tsukasaki K., Nagai K., Atogami S.,
RA   Sugahara K., Tsuruda K., Ishizaki A., Kamihira S.;
RT   "Activation of p53 by Nutlin-3a, an antagonist of MDM2, induces
RT   apoptosis and cellular senescence in adult T-cell leukemia cells.";
RL   Leukemia 23:2090-2101(2009).
//
RX   PubMed=29892436; DOI=10.1098/rsos.172472; PMCID=PMC5990783;
RA   Shioda S., Kasai F., Watanabe K., Kawakami K., Ohtani A., Iemura M.,
RA   Ozawa M., Arakawa A., Hirayama N., Kawaguchi E., Tano T., Miyata S.,
RA   Satoh M., Shimizu N., Kohara A.;
RT   "Screening for 15 pathogenic viruses in human cell lines registered at
RT   the JCRB Cell Bank: characterization of in vitro human cells by viral
RT   infection.";
RL   R. Soc. Open Sci. 5:172472-172472(2018).
//