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Cellosaurus THLE-5B (CVCL_M209)

[Text version]
Cell line name THLE-5B
Synonyms THLE-5b; THLE5B; THLE-5; Transformed Human Liver Epithelial-5B
Accession CVCL_M209
Resource Identification Initiative To cite this cell line use: THLE-5B (RRID:CVCL_M209)
Comments Group: Patented cell line.
Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-11113.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Cell type: Epithelial cell; CL=CL_0000066.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_IQ12 (THLE-5B-1A1)CVCL_IQ13 (THLE-5B-1A2)CVCL_IQ14 (THLE-5B-2A6)
CVCL_IQ15 (THLE-5B-2B6)CVCL_IQ16 (THLE-5B-2C19)CVCL_IQ17 (THLE-5B-2C9)
CVCL_IQ18 (THLE-5B-2D6)CVCL_IQ19 (THLE-5B-2E1)CVCL_IQ20 (THLE-B5-3A4)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Transformed cell line
Publications

DOI=10.1007/978-1-4612-0411-4_31
Lechner J.F., Smoot D.T., Pfeifer A.M.A., Cole K.H., Weston A., Groopman J.D., Shields P.G., Tokiwa T., Harris C.C.
A non-tumorigenic human liver epithelial cell culture model for chemical and biological carcinogenesis investigations.
(In) Neoplastic transformation in human cell system. Mechanism of carcinogenesis; Rhim J.S., Dritschilo A. (eds.); pp.307-321; Humana Press; New York (1990)

PubMed=7972006; DOI=10.1073/pnas.91.23.11045
Okamoto A., Demetrick D.J., Spillare E.A., Hagiwara K., Hussain S.P., Bennett W.P., Forrester K., Gerwin B.I., Serrano M., Beach D.H., Harris C.C.
Mutations and altered expression of p16INK4 in human cancer.
Proc. Natl. Acad. Sci. U.S.A. 91:11045-11049(1994)

Patent=US5506131
Harris C.C., Gelboin H.V., Gonzalez F.J., Mace K., Pfeifer A.M.A.
Immortalized human cell lines containing exogenous cytochrome P450 genes.
Patent number US5506131, 09-Apr-1996

PubMed=16962796; DOI=10.1016/j.cellbi.2006.07.006
Tokiwa T., Yamazaki T., Xin W., Sugae N., Noguchi M., Enosawa S., Tsukiyama T.
Differentiation potential of an immortalized non-tumorigenic human liver epithelial cell line as liver progenitor cells.
Cell Biol. Int. 30:992-998(2006)

PubMed=18157683; DOI=10.1007/s11626-007-9071-z
Yamazaki T., Enosawa S., Tsukiyama T., Tokiwa T.
Presence of side-population cells in an immortalized nontumorigenic human liver epithelial cell line.
In Vitro Cell. Dev. Biol. Anim. 44:6-9(2008)

PubMed=33495943; DOI=10.1007/s13577-021-00487-2
Yamazaki T., Tokiwa T.
Elevated levels of expression of cytochrome P450 3A4 in a human liver epithelial cell line in differentiation-inducing conditions.
Hum. Cell 34:750-758(2021)

Cross-references
Anatomy/cell type resources BTO; BTO:0005782
Encyclopedic resources Wikidata; Q54972313
Gene expression databases ArrayExpress; E-MTAB-7847
Entry history
Entry creation06-May-2013
Last entry update05-Oct-2023
Version number16