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Cellosaurus THLE-5B (CVCL_M209)

[Text version]
Cell line name THLE-5B
Synonyms THLE-5b; THLE5B; THLE-5; Transformed Human Liver Epithelial-5B
Accession CVCL_M209
Resource Identification Initiative To cite this cell line use: THLE-5B (RRID:CVCL_M209)
Comments Group: Patented cell line.
Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-11113.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Omics: Transcriptomics; RNAseq.
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Cell type: Epithelial cell; CL=CL_0000066.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_IQ12 (THLE-5B-1A1)CVCL_IQ13 (THLE-5B-1A2)CVCL_IQ14 (THLE-5B-2A6)
CVCL_IQ15 (THLE-5B-2B6)CVCL_IQ16 (THLE-5B-2C19)CVCL_IQ17 (THLE-5B-2C9)
CVCL_IQ18 (THLE-5B-2D6)CVCL_IQ19 (THLE-5B-2E1)CVCL_IQ20 (THLE-B5-3A4)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Transformed cell line
Publications

DOI=10.1007/978-1-4612-0411-4_31
John F. Lechner, Duane T. Smoot, Andrea M.A. Pfeifer, Katharine H. Cole, Ainsley Weston, John D. Groopman, Peter G. Shields, Takayoshi Tokiwa, Curtis Craig Harris;
A non-tumorigenic human liver epithelial cell culture model for chemical and biological carcinogenesis investigations.
(In book chapter) Neoplastic transformation in human cell system. Mechanism of carcinogenesis; Rhim, Johng Sik & Dritschilo, Anatoly (eds.); pp.307-321; Humana Press; New York; USA (1990)

PubMed=7972006; DOI=10.1073/pnas.91.23.11045; PMCID=PMC45163
Aikou Okamoto, Douglas J. Demetrick, Elisa A. Spillare, Koichi Hagiwara, S. Perwez Hussain, William P. Bennett, Kathleen Forrester, Brenda Isen Gerwin, Manuel Serrano, David H. Beach, Curtis Craig Harris;
Mutations and altered expression of p16INK4 in human cancer.
Proc. Natl. Acad. Sci. U.S.A. 91:11045-11049(1994)

Patent=US5506131
Curtis Craig Harris, Harry Victor Gelboin, Frank J. Gonzalez, Katherine Mace, Andrea M.A. Pfeifer;
Immortalized human cell lines containing exogenous cytochrome P450 genes.
Patent number US5506131, 09-Apr-1996

PubMed=16962796; DOI=10.1016/j.cellbi.2006.07.006
Takayoshi Tokiwa, Taisuke Yamazaki, W. Xin, N. Sugae, Masayuki Noguchi, Shin Enosawa, Tomoyuki Tsukiyama;
Differentiation potential of an immortalized non-tumorigenic human liver epithelial cell line as liver progenitor cells.
Cell Biol. Int. 30:992-998(2006)

PubMed=18157683; DOI=10.1007/s11626-007-9071-z
Taisuke Yamazaki, Shin Enosawa, Tomoyuki Tsukiyama, Takayoshi Tokiwa;
Presence of side-population cells in an immortalized nontumorigenic human liver epithelial cell line.
In Vitro Cell. Dev. Biol. Anim. 44:6-9(2008)

PubMed=33495943; DOI=10.1007/s13577-021-00487-2
Taisuke Yamazaki, Takayoshi Tokiwa;
Elevated levels of expression of cytochrome P450 3A4 in a human liver epithelial cell line in differentiation-inducing conditions.
Hum. Cell 34:750-758(2021)

Cross-references
Anatomy/cell type resources BTO; BTO_0005782
Encyclopedic resources Wikidata; Q54972313
Gene expression databases ArrayExpress; E-MTAB-7847
Entry history
Entry creation06-May-2013
Last entry update10-Apr-2025
Version number18