ID   THLE-5B
AC   CVCL_M209
SY   THLE-5b; THLE5B; THLE-5; Transformed Human Liver Epithelial-5B
DR   BTO; BTO:0005782
DR   ArrayExpress; E-MTAB-7847
DR   Wikidata; Q54972313
RX   DOI=10.1007/978-1-4612-0411-4_31;
RX   Patent=US5506131;
RX   PubMed=7972006;
RX   PubMed=16962796;
RX   PubMed=18157683;
RX   PubMed=33495943;
CC   Group: Patented cell line.
CC   Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-11113.
CC   Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
CC   Omics: Transcriptome analysis by RNAseq.
CC   Derived from site: In situ; Liver; UBERON=UBERON_0002107.
CC   Cell type: Epithelial cell; CL=CL_0000066.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Sex unspecified
AG   Age unspecified
CA   Transformed cell line
DT   Created: 06-05-13; Last updated: 05-10-23; Version: 16
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RX   DOI=10.1007/978-1-4612-0411-4_31;
RA   Lechner J.F., Smoot D.T., Pfeifer A.M.A., Cole K.H., Weston A.,
RA   Groopman J.D., Shields P.G., Tokiwa T., Harris C.C.;
RT   "A non-tumorigenic human liver epithelial cell culture model for
RT   chemical and biological carcinogenesis investigations.";
RL   (In) Neoplastic transformation in human cell system. Mechanism of carcinogenesis; Rhim J.S., Dritschilo A. (eds.); pp.307-321; Humana Press; New York (1990).
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RX   Patent=US5506131;
RA   Harris C.C., Gelboin H.V., Gonzalez F.J., Mace K., Pfeifer A.M.A.;
RT   "Immortalized human cell lines containing exogenous cytochrome P450
RT   genes.";
RL   Patent number US5506131, 09-Apr-1996.
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RX   PubMed=7972006; DOI=10.1073/pnas.91.23.11045;
RA   Okamoto A., Demetrick D.J., Spillare E.A., Hagiwara K., Hussain S.P.,
RA   Bennett W.P., Forrester K., Gerwin B.I., Serrano M., Beach D.H.,
RA   Harris C.C.;
RT   "Mutations and altered expression of p16INK4 in human cancer.";
RL   Proc. Natl. Acad. Sci. U.S.A. 91:11045-11049(1994).
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RX   PubMed=16962796; DOI=10.1016/j.cellbi.2006.07.006;
RA   Tokiwa T., Yamazaki T., Xin W., Sugae N., Noguchi M., Enosawa S.,
RA   Tsukiyama T.;
RT   "Differentiation potential of an immortalized non-tumorigenic human
RT   liver epithelial cell line as liver progenitor cells.";
RL   Cell Biol. Int. 30:992-998(2006).
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RX   PubMed=18157683; DOI=10.1007/s11626-007-9071-z;
RA   Yamazaki T., Enosawa S., Tsukiyama T., Tokiwa T.;
RT   "Presence of side-population cells in an immortalized nontumorigenic
RT   human liver epithelial cell line.";
RL   In Vitro Cell. Dev. Biol. Anim. 44:6-9(2008).
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RX   PubMed=33495943; DOI=10.1007/s13577-021-00487-2;
RA   Yamazaki T., Tokiwa T.;
RT   "Elevated levels of expression of cytochrome P450 3A4 in a human liver
RT   epithelial cell line in differentiation-inducing conditions.";
RL   Hum. Cell 34:750-758(2021).
//