Cellosaurus logo
expasy logo

Cellosaurus HepG2/Adm (CVCL_M187)

[Text][XML][JSON]
Cell line name HepG2/Adm
Synonyms HepG2/ADM; Hep-G2/ADM; Hep G2/ADM
Accession CVCL_M187
Resource Identification Initiative To cite this cell line use: HepG2/Adm (RRID:CVCL_M187)
Comments Population: Caucasian.
Doubling time: 30.1 hours (PubMed=15087025).
Selected for resistance to: ChEBI; CHEBI_28748; Doxorubicin (Adriablastin; Adriamycin).
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Hepatoblastoma (NCIt: C3728)
Hepatoblastoma (ORDO: Orphanet_449)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0027 (Hep-G2)
Sex of cell Male
Age at sampling 15Y
Category Cancer cell line
Publications

PubMed=14980111
Bao-Jin Zhai, Feng Wu, Ze-Yong Shao, Kai Hu, Chun-Liang Zhao, Zhi-Biao Wang;
Establishment of human hepatocellular carcinoma multidrug-resistance cell line (HepG2/Adm) and study apoptosis induced by low-frequency pulse ultrasound exposure.
Zhonghua Gan Zang Bing Za Zhi 12:95-98(2004)

PubMed=15087025
Bao-Jin Zhai, Feng Wu, Ze-Yong Shao, Kai Hu, Zhi-Biao Wang;
Establishment of human multidrug-resistant hepatocellular carcinoma cell line (HepG2/Adm) and biological characteristics evaluation.
Ai Zheng 23:391-395(2004)

PubMed=17075973; DOI=10.3748/wjg.v12.i41.6614; PMCID=PMC4125665
Bao-Jin Zhai, Ze-Yong Shao, Chun-Liang Zhao, Kai Hu, Feng Wu;
Development and characterization of multidrug resistant human hepatocarcinoma cell line in nude mice.
World J. Gastroenterol. 12:6614-6619(2006)

Cross-references
Cell line databases/resources cancercelllines; CVCL_M187
Anatomy/cell type resources BTO; BTO_0006029
Chemistry resources ChEMBL-Cells; CHEMBL4482252
PubChem_Cell_line; CVCL_M187
Encyclopedic resources Wikidata; Q54882859
Entry history
Entry creation06-May-2013
Last entry update27-Nov-2025
Version number20