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Cellosaurus HepG2/mdr1 (CVCL_M186)

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Cell line name HepG2/mdr1
Accession CVCL_M186
Resource Identification Initiative To cite this cell line use: HepG2/mdr1 (RRID:CVCL_M186)
Comments Population: Caucasian.
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:40; ABCB1.
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Hepatoblastoma (NCIt: C3728)
Hepatoblastoma (ORDO: Orphanet_449)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0027 (Hep-G2)
Sex of cell Male
Age at sampling 15Y
Category Cancer cell line
Publications

PubMed=17517188; DOI=10.5555/cmj.0366-6999.120.08.p703.01
Yong-Bing Chen, Mao-Lin Yan, Jian-Ping Gong, Ren-Pin Xia, Li-Xin Liu, Ning Li, Shi-Chun Lu, Jing-Guang Zhang, Dao-Bing Zeng, Jian-Guo Xie, Jia-Yin Yang, Lu-Nan Yan;
Establishment of hepatocellular carcinoma multidrug resistant monoclone cell line HepG2/mdr1.
Chin. Med. J. 120:703-707(2007)

Cross-references
Cell line databases/resources cancercelllines; CVCL_M186
Encyclopedic resources Wikidata; Q54882860
Entry history
Entry creation06-May-2013
Last entry update27-Nov-2025
Version number19