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Cellosaurus COG-LL-317h (CVCL_M160)

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Cell line name COG-LL-317h
Accession CVCL_M160
Resource Identification Initiative To cite this cell line use: COG-LL-317h (RRID:CVCL_M160)
Comments Part of: NCI Pediatric Preclinical Testing Program (PPTP) cell line panel.
Characteristics: Hypoxic cell line grown at 5% O2.
Doubling time: 19-20 hours (COG).
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Cell type: T-cell; CL=CL_0000084.
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_M159 ! COG-LL-317
Sex of cell Male
Age at sampling 1Y7M
Category Cancer cell line
STR profile Source(s): COG

Markers:
AmelogeninX,Y
CSF1PO10
D2S133817,18
D3S135816,17
D5S81811,13
D7S82011,13
D8S117915
D13S3178,12
D16S5399,11
D18S5114,18
D19S43314,16
D21S1130
FGA20,23
TH017,8
TPOX8,11
vWA16,17

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Web pages Provider; CCR; -; https://www.cccells.org/tables/Lymp_N.php
Publications

PubMed=22137317; DOI=10.1016/j.leukres.2011.10.022; PMCID=PMC3264762
Chong Zhang, Yong-Ku Ryu, Taylor Z. Chen, Connor P. Hall, Daniel R. Webster, Min H. Kang;
Synergistic activity of rapamycin and dexamethasone in vitro and in vivo in acute lymphoblastic leukemia via cell-cycle arrest and apoptosis.
Leuk. Res. 36:342-349(2012)

PubMed=26080839; DOI=10.1158/1078-0432.CCR-15-0114; PMCID=PMC4681691
Connor P. Hall, Charles Patrick Reynolds, Min H. Kang;
Modulation of glucocorticoid resistance in pediatric T-cell acute lymphoblastic leukemia by increasing BIM expression with the PI3K/mTOR inhibitor BEZ235.
Clin. Cancer Res. 22:621-632(2016)

PubMed=28119491; DOI=10.1158/1535-7163.MCT-16-0749
Monish Ram Makena, Balakrishna Koneru, Thinh H. Nguyen, Min H. Kang, Charles Patrick Reynolds;
Reactive oxygen species-mediated synergism of fenretinide and romidepsin in preclinical models of T-cell lymphoid malignancies.
Mol. Cancer Ther. 16:649-661(2017)

Cross-references
Encyclopedic resources Wikidata; Q54813970
Entry history
Entry creation06-May-2013
Last entry update10-Apr-2025
Version number16