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Cellosaurus CHLA-9 (CVCL_M150)

[Text version]
Cell line name CHLA-9
Synonyms CHLA9
Accession CVCL_M150
Resource Identification Initiative To cite this cell line use: CHLA-9 (RRID:CVCL_M150)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: MD Anderson Cell Lines Project.
Part of: NCI Pediatric Preclinical Testing Program (PPTP) cell line panel.
Doubling time: 20 hours (PubMed=20922763); 51 hours (PubMed=24312454).
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Transcriptomics; RNAseq.
Omics: Transcriptomics; RNAseq; Single cell.
Derived from site: In situ; Thorax; UBERON=UBERON_0000915.
Sequence variations
  • Gene fusion; HGNC; HGNC:3508; EWSR1 + HGNC; HGNC:3749; FLI1; Name(s)=EWSR1-FLI1, EWS-FLI1; Note=Type 1 fusion (Ex7/Ex6) (PubMed=25010205).
  • Mutation; HGNC; HGNC:11355; STAG2; Simple; p.Val628insThrAspIle; Zygosity=Unspecified (PubMed=25010205).
Disease Primitive neuroectodermal tumor (NCIt: C3716)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_6583 ! CHLA-10
Sex of cell Female
Age at sampling 14Y
Category Cancer cell line
STR profile Source(s): COG; PubMed=20922763; PubMed=24312454; PubMed=25010205

Markers:
AmelogeninX
CSF1PO12
D2S133819,20
D3S135815,16
D5S81812
D7S8209,10
D8S117910,13
D13S31711,12
D16S53911
D18S5112,14
D19S43312,13
D21S1128,29
FGA23,24
TH017,9.3
TPOX8,11
vWA16,17

Run an STR similarity search on this cell line
Web pages Info; MCLP; -; https://tcpaportal.org/mclp/
Provider; CCR; -; https://www.cccells.org/PDF_Files/Brain/CHLA-9%20Cell%20Line%20Data%20Sheet.pdf
Provider; CCR; -; https://www.cccells.org/tables/Ewings.php
Publications

PubMed=15289350; DOI=10.1158/0008-5472.CAN-04-0377
Sandeep Batra, Charles Patrick Reynolds, Barry J. Maurer;
Fenretinide cytotoxicity for Ewing's sarcoma and primitive neuroectodermal tumor cell lines is decreased by hypoxia and synergistically enhanced by ceramide modulators.
Cancer Res. 64:5415-5424(2004)

PubMed=20922763; DOI=10.1002/pbc.22801; PMCID=PMC3005554
Min H. Kang, Malcolm A. Smith, Christopher L. Morton, Nino Keshelava, Peter J. Houghton, Charles Patrick Reynolds;
National Cancer Institute pediatric preclinical testing program: model description for in vitro cytotoxicity testing.
Pediatr. Blood Cancer 56:239-249(2011)

PubMed=24312454; DOI=10.1371/journal.pone.0080060; PMCID=PMC3846563
William A. May, Rita S. Grigoryan, Nino Keshelava, Daniel J. Cabral, Laura L. Christensen, Jasmine Jenabi, Ling-Yun Ji, Timothy J. Triche, Elizabeth R. Lawlor, Charles Patrick Reynolds;
Characterization and drug resistance patterns of Ewing's sarcoma family tumor cell lines.
PLoS ONE 8:e80060.1-e80060.10(2013)

PubMed=25010205; DOI=10.1371/journal.pgen.1004475; PMCID=PMC4091782
Andrew S. Brohl, David A. Solomon, Wendy Chang, Jian-Jun Wang, Young Song, Sivasish Sindiri, Rajesh Patidar, Laura Hurd, Li Chen, Jack F. Shern, Hong-Ling Liao ...Show all 26 authors... , Xin-Yu Wen, Julia Gerard, Jung-Sik Kim, Jose Antonio Lopez Guerrero, Isidro Machado, Daniel H. Wai, Piero Picci, Timothy J. Triche, Andrew E. Horvai, Markku Martti Miettinen, Jun S. Wei, Daniel Catchpoole, Antonio Llombart-Bosch, Todd A. Waldman, Javed Khan; Show fewer authors
The genomic landscape of the Ewing sarcoma family of tumors reveals recurrent STAG2 mutation.
PLoS Genet. 10:e1004475.1-e1004475.13(2014)

PubMed=26351324; DOI=10.1158/1535-7163.MCT-15-0074; PMCID=PMC4636476
Beverly A. Teicher, Eric C. Polley, Mark W. Kunkel, David Evans, Thomas E. Silvers, Rene M. Delosh, Julie Laudeman, Chad Ogle, Russell Reinhart, Michael Selby, John Connelly ...Show all 14 authors... , Erik Harris, Anne Monks, Joel Morris; Show fewer authors
Sarcoma cell line screen of oncology drugs and investigational agents identifies patterns associated with gene and microRNA expression.
Mol. Cancer Ther. 14:2452-2462(2015)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076
Jun Li, Wei Zhao, Rehan Akbani, Wen-Bin Liu, Zhen-Lin Ju, Shi-Yun Ling, Christopher P. Vellano, Paul Roebuck, Qing-Hua Yu, A. Karina Eterovic, Lauren Averett Byers ...Show all 25 authors... , Michael A. Davies, Wan-Leng Deng, Y.N. Vashisht Gopal, Guo Chen, Erika Maria von Euw, Dennis Joseph Slamon, Dylan Conklin, John Victor Heymach, Adi F. Gazdar, John D. Minna, Jeffrey N. Myers, Yi-Ling Lu, Gordon B. Mills, Han Liang; Show fewer authors
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

Cross-references
Cell line databases/resources cancercelllines; CVCL_M150
Cell_Model_Passport; SIDM01534
DepMap; ACH-001034
Encyclopedic resources Wikidata; Q54812509
Gene expression databases GEO; GSM1676339
GEO; GSM1701626
GEO; GSM4368462
Polymorphism and mutation databases Cosmic; 2228220
Entry history
Entry creation06-May-2013
Last entry update10-Apr-2025
Version number23