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Cellosaurus MN9D (CVCL_M067)

[Text version]
Cell line name MN9D
Synonyms MN-9D
Accession CVCL_M067
Resource Identification Initiative To cite this cell line use: MN9D (RRID:CVCL_M067)
Comments Characteristics: Extensively used to model dopaminergic neurons and to test mechanisms and potential therapeutics relevant to the loss of DA neurons in Parkinson's disease (Millipore=SCC281).
Characteristics: Fusion of N18TG2 with rostral mesencephalic neurons from a 14-day-old C57BL/6J mouse embryo (PubMed=1913182).
Selected for resistance to: ChEBI; CHEBI:9555; Tioguanine (6-thioguanine; 6-TG).
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Hierarchy Parent: CVCL_2132 (N18TG2)
Category Hybrid cell line
STR profile Source(s): Millipore

Mouse STR 1-111,17
Mouse STR 1-217,19
Mouse STR 2-116
Mouse STR 3-213,14
Mouse STR 4-220.3,22.3
Mouse STR 5-515,17
Mouse STR 6-418,20
Mouse STR 6-712,17
Mouse STR 7-125.2
Mouse STR 8-116,17
Mouse STR 11-215,16
Mouse STR 12-116,17
Mouse STR 13-116.2,17.2,18.2
Mouse STR 15-322.3,23.3
Mouse STR 17-215,16
Mouse STR 18-316,22
Mouse STR 19-212,13
Mouse STR X-125,28,29

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PubMed=1913182; DOI=10.1016/0006-8993(91)90661-E
Choi H.K., Won L.A., Kontur P.J., Hammond D.N., Fox A.P., Wainer B.H., Hoffmann P.C., Heller A.
Immortalization of embryonic mesencephalic dopaminergic neurons by somatic cell fusion.
Brain Res. 552:67-76(1991)

PubMed=1357658; DOI=10.1073/pnas.89.19.8943
Choi H.K., Won L.A., Roback J.D., Wainer B.H., Heller A.
Specific modulation of dopamine expression in neuronal hybrid cells by primary cells from different brain regions.
Proc. Natl. Acad. Sci. U.S.A. 89:8943-8947(1992)

PubMed=17028430; DOI=10.1159/000095115
Rick C.E., Ebert A., Virag T., Bohn M.C., Surmeier D.J.
Differentiated dopaminergic MN9D cells only partially recapitulate the electrophysiological properties of midbrain dopaminergic neurons.
Dev. Neurosci. 28:528-537(2006)

Cell line collections (Providers) Millipore; SCC281
Cell line databases/resources Lonza; 979
Anatomy/cell type resources BTO; BTO:0003945
Encyclopedic resources Wikidata; Q54906266
Experimental variables resources EFO; EFO_0006455
Entry history
Entry creation06-May-2013
Last entry update29-Jun-2023
Version number10