ID   MN9D
AC   CVCL_M067
SY   MN-9D
DR   BTO; BTO_0003945
DR   EFO; EFO_0006455
DR   Lonza; 979
DR   Millipore; SCC281
DR   Wikidata; Q54906266
RX   PubMed=1357658;
RX   PubMed=1913182;
RX   PubMed=17028430;
CC   Characteristics: Extensively used to model dopaminergic neurons and to test mechanisms and potential therapeutics relevant to the loss of DA neurons in Parkinson's disease (Millipore=SCC281).
CC   Characteristics: Fusion of N18TG2 with rostral mesencephalic neurons from a 14-day-old C57BL/6J mouse embryo (PubMed=1913182).
CC   Selected for resistance to: ChEBI; CHEBI_9555; Tioguanine (6-thioguanine; 6-TG).
ST   Source(s): Millipore=SCC281
ST   Mouse STR 1-1: 11,17
ST   Mouse STR 1-2: 17,19
ST   Mouse STR 2-1: 16
ST   Mouse STR 3-2: 13,14
ST   Mouse STR 4-2: 20.3,22.3
ST   Mouse STR 5-5: 15,17
ST   Mouse STR 6-4: 18,20
ST   Mouse STR 6-7: 12,17
ST   Mouse STR 7-1: 25.2
ST   Mouse STR 8-1: 16,17
ST   Mouse STR 11-2: 15,16
ST   Mouse STR 12-1: 16,17
ST   Mouse STR 13-1: 16.2,17.2,18.2
ST   Mouse STR 15-3: 22.3,23.3
ST   Mouse STR 17-2: 15,16
ST   Mouse STR 18-3: 16,22
ST   Mouse STR 19-2: 12,13
ST   Mouse STR X-1: 25,28,29
OX   NCBI_TaxID=10090; ! Mus musculus (Mouse)
HI   CVCL_2132 ! N18TG2
CA   Hybrid cell line
DT   Created: 06-05-13; Last updated: 10-04-25; Version: 13
//
RX   PubMed=1913182; DOI=10.1016/0006-8993(91)90661-E;
RA   Choi, Hyung K.
RA   Won, Lisa A.
RA   Kontur, Paul J.
RA   Hammond, David N.
RA   Fox, Aaron P.
RA   Wainer, Bruce H.
RA   Hoffmann, Philip C.
RA   Heller, Alfred
RT   "Immortalization of embryonic mesencephalic dopaminergic neurons by
RT   somatic cell fusion.";
RL   Brain Res. 552:67-76(1991).
//
RX   PubMed=17028430; DOI=10.1159/000095115;
RA   Rick, Caroline E.
RA   Ebert, Allison D.
RA   Virag, Tamas
RA   Bohn, Martha C.
RA   Surmeier, Dalton James
RT   "Differentiated dopaminergic MN9D cells only partially recapitulate
RT   the electrophysiological properties of midbrain dopaminergic
RT   neurons.";
RL   Dev. Neurosci. 28:528-537(2006).
//
RX   PubMed=1357658; DOI=10.1073/pnas.89.19.8943; PMCID=PMC50040;
RA   Choi, Hyung K.
RA   Won, Lisa A.
RA   Roback, John D.
RA   Wainer, Bruce H.
RA   Heller, Alfred
RT   "Specific modulation of dopamine expression in neuronal hybrid cells
RT   by primary cells from different brain regions.";
RL   Proc. Natl. Acad. Sci. U.S.A. 89:8943-8947(1992).
//