AC   CVCL_M067
SY   MN-9D
DR   BTO; BTO:0003945
DR   EFO; EFO_0006455
DR   Lonza; 979
DR   Millipore; SCC281
DR   Wikidata; Q54906266
RX   PubMed=1357658;
RX   PubMed=1913182;
RX   PubMed=17028430;
CC   Characteristics: Extensively used to model dopaminergic neurons and to test mechanisms and potential therapeutics relevant to the loss of DA neurons in Parkinson's disease (Millipore=SCC281).
CC   Characteristics: Fusion of N18TG2 with rostral mesencephalic neurons from a 14-day-old C57BL/6J mouse embryo (PubMed=1913182).
CC   Selected for resistance to: ChEBI; CHEBI:9555; Tioguanine (6-thioguanine; 6-TG).
ST   Source(s): Millipore=SCC281
ST   Mouse STR 1-1: 11,17
ST   Mouse STR 1-2: 17,19
ST   Mouse STR 11-2: 15,16
ST   Mouse STR 12-1: 16,17
ST   Mouse STR 13-1: 16.2,17.2,18.2
ST   Mouse STR 15-3: 22.3,23.3
ST   Mouse STR 17-2: 15,16
ST   Mouse STR 18-3: 16,22
ST   Mouse STR 19-2: 12,13
ST   Mouse STR 2-1: 16
ST   Mouse STR 3-2: 13,14
ST   Mouse STR 4-2: 20.3,22.3
ST   Mouse STR 5-5: 15,17
ST   Mouse STR 6-4: 18,20
ST   Mouse STR 6-7: 12,17
ST   Mouse STR 7-1: 25.2
ST   Mouse STR 8-1: 16,17
ST   Mouse STR X-1: 25,28,29
OX   NCBI_TaxID=10090; ! Mus musculus (Mouse)
HI   CVCL_2132 ! N18TG2
CA   Hybrid cell line
DT   Created: 06-05-13; Last updated: 02-05-24; Version: 11
RX   PubMed=1357658; DOI=10.1073/pnas.89.19.8943;
RA   Choi H.K., Won L.A., Roback J.D., Wainer B.H., Heller A.;
RT   "Specific modulation of dopamine expression in neuronal hybrid cells
RT   by primary cells from different brain regions.";
RL   Proc. Natl. Acad. Sci. U.S.A. 89:8943-8947(1992).
RX   PubMed=1913182; DOI=10.1016/0006-8993(91)90661-E;
RA   Choi H.K., Won L.A., Kontur P.J., Hammond D.N., Fox A.P., Wainer B.H.,
RA   Hoffmann P.C., Heller A.;
RT   "Immortalization of embryonic mesencephalic dopaminergic neurons by
RT   somatic cell fusion.";
RL   Brain Res. 552:67-76(1991).
RX   PubMed=17028430; DOI=10.1159/000095115;
RA   Rick C.E., Ebert A.D., Virag T., Bohn M.C., Surmeier D.J.;
RT   "Differentiated dopaminergic MN9D cells only partially recapitulate
RT   the electrophysiological properties of midbrain dopaminergic
RT   neurons.";
RL   Dev. Neurosci. 28:528-537(2006).