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Cellosaurus HB1.F3.Ras (CVCL_LJ48)

[Text version]
Cell line name HB1.F3.Ras
Synonyms F3.Ras
Accession CVCL_LJ48
Resource Identification Initiative To cite this cell line use: HB1.F3.Ras (RRID:CVCL_LJ48)
Comments Characteristics: Tumorigenic, forms brain cancers when injected in mouse brains.
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:5173; HRAS (Note=With p.Gly12Val).
Genetic integration: Method=Transduction; Gene=UniProtKB; P01110; Avian myelocytomatosis virus 29 v-Myc.
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR).
Transformant: v-Myc.
Omics: Transcriptomics; Microarray.
Derived from site: In situ; Fetal brain, telencephalon; UBERON=UBERON_0014371.
Cell type: Neural stem cell; CL=CL_0000047.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_LJ44 (HB1.F3)
Sex of cell Female
Age at sampling 14FW
Category Transformed cell line
Publications

PubMed=21755312; DOI=10.1007/s12015-011-9280-4; PMCID=PMC4043123
Ji-Seon Lee, Hong Jun Lee, Bo-Hyun Moon, Seung-Hyun Song, Mi-Ok Lee, Sung Han Shim, Hyung Seok Kim, Min Cheol Lee, Jeong Taik Kwon, Albert J. Fornace Jr., Seung U. Kim, Hyuk-Jin Cha;
Generation of cancerous neural stem cells forming glial tumor by oncogenic stimulation.
Stem Cell Rev. Rep. 8:532-545(2012)

PubMed=25096191; DOI=10.1093/neuonc/nou145; PMCID=PMC4483050
Ji-Seon Lee, Jeong-Rak Park, Ok-Seon Kwon, Tae-Hee Lee, Ichiro Nakano, Hiroyuki Miyoshi, Kwang-Hoon Chun, Myung-Jin Park, Hong Jun Lee, Seung U. Kim, Hyuk-Jin Cha;
SIRT1 is required for oncogenic transformation of neural stem cells and for the survival of 'cancer cells with neural stemness' in a p53-dependent manner.
Neuro-oncol. 17:95-106(2015)

Cross-references
Encyclopedic resources Wikidata; Q54881356
Entry history
Entry creation15-Nov-2017
Last entry update14-Aug-2025
Version number11