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Cellosaurus HB1.F3 (CVCL_LJ44)

[Text version]
Cell line name HB1.F3
Synonyms F3; F3-WT
Accession CVCL_LJ44
Resource Identification Initiative To cite this cell line use: HB1.F3 (RRID:CVCL_LJ44)
Comments Genetic integration: Method=Transduction; Gene=UniProtKB; P01110; Avian myelocytomatosis virus 29 v-Myc.
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Transformant: v-Myc.
Omics: Transcriptomics; Microarray.
Derived from site: In situ; Fetal brain, telencephalon; UBERON=UBERON_0014371.
Cell type: Neural stem cell; CL=CL_0000047.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_B7F6 (F3-effLuc)CVCL_LJ45 (HB1.F3.CD21)CVCL_LJ46 (HB1.F3.EGFRviii)
CVCL_E3V6 (HB1.F3.NeuroD)CVCL_LJ47 (HB1.F3.Ngn1)CVCL_LJ48 (HB1.F3.Ras)
Sex of cell Female
Age at sampling 14FW
Category Transformed cell line
Publications

PubMed=12167771; DOI=10.1097/00001756-200208070-00020
Taesup Cho, Jae-Hoon Bae, Hyun B. Choi, Sung Soon Kim, James G. McLarnon, Haeyoung Suh-Kim, Seung U. Kim, Churl K. Min;
Human neural stem cells: electrophysiological properties of voltage-gated ion channels.
NeuroReport 13:1447-1452(2002)

PubMed=15484694; DOI=10.1111/j.1440-1789.2004.00552.x
Seung U. Kim;
Human neural stem cells genetically modified for brain repair in neurological disorders.
Neuropathology 24:159-171(2004)

PubMed=19813087; DOI=10.1007/s10571-009-9466-3
Jun-ichi Satoh, Shinya Obayashi, Hiroko Tabunoki, Taeko Wakana, Seung U. Kim;
Stable expression of neurogenin 1 induces LGR5, a novel stem cell marker, in an immortalized human neural stem cell line HB1.F3.
Cell. Mol. Neurobiol. 30:415-426(2010)

PubMed=21755312; DOI=10.1007/s12015-011-9280-4; PMCID=PMC4043123
Ji-Seon Lee, Hong Jun Lee, Bo-Hyun Moon, Seung-Hyun Song, Mi-Ok Lee, Sung Han Shim, Hyung Seok Kim, Min Cheol Lee, Jeong Taik Kwon, Albert J. Fornace Jr., Seung U. Kim, Hyuk-Jin Cha;
Generation of cancerous neural stem cells forming glial tumor by oncogenic stimulation.
Stem Cell Rev. Rep. 8:532-545(2012)

PubMed=25198726; DOI=10.1371/journal.pone.0105129; PMCID=PMC4157740
Do Won Hwang, Yeona Jin, Do Hun Lee, Han Young Kim, Han Na Cho, Hye Jin Chung, Yunwoong Park, Hyewon Youn, Seung Jin Lee, Hong J. Lee, Seung U. Kim ...Show all 13 authors... , Kyu-Chang Wang, Dong Soo Lee; Show fewer authors
In vivo bioluminescence imaging for prolonged survival of transplanted human neural stem cells using 3D biocompatible scaffold in corticectomized rat model.
PLoS ONE 9:e105129.1-e105129.11(2014)

PubMed=25096191; DOI=10.1093/neuonc/nou145; PMCID=PMC4483050
Ji-Seon Lee, Jeong-Rak Park, Ok-Seon Kwon, Tae-Hee Lee, Ichiro Nakano, Hiroyuki Miyoshi, Kwang-Hoon Chun, Myung-Jin Park, Hong Jun Lee, Seung U. Kim, Hyuk-Jin Cha;
SIRT1 is required for oncogenic transformation of neural stem cells and for the survival of 'cancer cells with neural stemness' in a p53-dependent manner.
Neuro-oncol. 17:95-106(2015)

PubMed=28830458; DOI=10.1186/s12943-017-0703-y; PMCID=PMC5567886
Soo-Jung Kwon, Ok-Seon Kwon, Keun-Tae Kim, Young-Hyun Go, Si-In Yu, Byeong-Ha Lee, Hiroyuki Miyoshi, Eunsel Oh, Seung-Ju Cho, Hyuk-Jin Cha;
Role of MEK partner-1 in cancer stemness through MEK/ERK pathway in cancerous neural stem cells, expressing EGFRviii.
Mol. Cancer 16:140.1-140.13(2017)

Cross-references
Anatomy/cell type resources BTO; BTO_0002893
Encyclopedic resources Wikidata; Q54881352
Gene expression databases GEO; GSM456723
GEO; GSM456725
Entry history
Entry creation15-Nov-2017
Last entry update14-Aug-2025
Version number11