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Cellosaurus EBC-1 KRAS (G12D/+/+/+) (CVCL_LC83)

[Text version]
Cell line name EBC-1 KRAS (G12D/+/+/+)
Synonyms KRAS (G12D/+/+/+) EBC-1
Accession CVCL_LC83
Resource Identification Initiative To cite this cell line use: EBC-1 KRAS (G12D/+/+/+) (RRID:CVCL_LC83)
Comments Population: Japanese.
Characteristics: Heterozygous knockin of a KRAS activating mutation.
Derived from site: Metastatic; Skin; UBERON=UBERON_0002097.
Sequence variations
  • Mutation; HGNC; 2731; DDR2; Simple; p.Thr681Ile (c.2042C>T); ClinVar=VCV001435412; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6407; KRAS; Simple_edited; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous; Note=By method not specified (Horizon_Discovery=HD+121-001).
  • Mutation; HGNC; 11998; TP53; Simple; p.Glu171Ter (c.511G>T); ClinVar=VCV000634771; Zygosity=Homozygous (from parent cell line).
Disease Lung squamous cell carcinoma (NCIt: C3493)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2891 (EBC-1)
Sex of cell Male
Age at sampling 69Y
Category Cancer cell line
Cross-references
Cell line collections (Providers) Horizon_Discovery; HD+121-001
Cell line databases/resources cancercelllines; CVCL_LC83
Encyclopedic resources Wikidata; Q54831757
Entry history
Entry creation22-Aug-2017
Last entry update30-Jan-2024
Version number13