| Cell line name |
LIM1215 KRAS (G12R/+) |
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| Synonyms |
KRAS (G12R/+) LIM1215 |
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| Accession |
CVCL_LC76 |
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| Resource Identification Initiative |
To cite this cell line use: LIM1215 KRAS (G12R/+) (RRID:CVCL_LC76) |
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| Comments |
Population: Caucasian.
Characteristics: Heterozygous knockin of a KRAS activating mutation.
Derived from site: Metastatic; Omentum; UBERON=UBERON_0003688. |
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| Sequence variations |
- Mutation; HGNC; HGNC:173; ACVR2A; Simple; p.Pro423Gln (c.1268C>A); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:173; ACVR2A; Simple; p.Lys437Argfs*5 (c.1310delA); dbSNP=rs764719749; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Thr41Ala (c.121A>G); ClinVar=VCV000017580; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:6407; KRAS; Simple_edited; p.Gly12Arg (c.34G>C); ClinVar=VCV000012579; Zygosity=Heterozygous; Note=By method not specified (Horizon_Discovery=HD+116-002).
- Mutation; HGNC; HGNC:11773; TGFBR2; Simple; p.Lys128Serfs*35 (c.383delA); ClinVar=VCV000477546; Zygosity=Homozygous (from parent cell line).
|
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| Disease |
Colon adenocarcinoma (NCIt: C4349)
Lynch syndrome (NCIt: C8494)
Lynch syndrome (ORDO: Orphanet_144) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_2574 (LIM1215) |
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| Sex of cell |
Male |
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| Age at sampling |
34Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=22722830; DOI=10.1038/nature11156; PMCID=PMC3927413
Sandra Misale, Rona D. Yaeger, Sebastijan Hobor, Elisa Scala, Manickam Janakiraman, David Liska, Emanuele Valtorta, Roberta Schiavo, Michela Buscarino, Giulia Siravegna, Katia Bruna Bencardino ...Show all 26 authors... , Andrea Cercek, Chin-Tung Chen, Silvio Veronese, Carlo Zanon, Andrea Sartore-Bianchi, Marcello Gambacorta, Margherita Gallicchio, Efsevia Vakiani, Valentina Boscaro, Enzo Medico, Martin R. Weiser, Salvatore Siena, Federica Di Nicolantonio, David B. Solit, Alberto Bardelli; Show fewer authors
Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer.
Nature 486:532-536(2012) |
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| Cross-references |
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| Cell line collections (Providers) |
Horizon_Discovery; HD+116-002
|
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| Cell line databases/resources |
cancercelllines; CVCL_LC76
|
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| Encyclopedic resources |
Wikidata; Q54902522
|
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| Entry history |
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| Entry creation | 22-Aug-2017 |
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| Last entry update | 19-Dec-2024 |
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| Version number | 14 |
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