Cellosaurus logo
expasy logo

Cellosaurus BO2C11 (CVCL_LB95)

[Text][XML][JSON]
Cell line name BO2C11
Synonyms Bo2C11
Accession CVCL_LB95
Resource Identification Initiative To cite this cell line use: BO2C11 (RRID:CVCL_LB95)
Comments Characteristics: Produces a monoclonal antibody that completely inhibits the procoagulant activity of native and activated factor VIII.
Monoclonal antibody isotype: IgG4, kappa.
Monoclonal antibody target: UniProtKB; P00451; Human F8.
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Disease Hemophilia A (NCIt: C27146)
Hemophilia A (ORDO: Orphanet_98878)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 49Y
Category Transformed cell line
Publications

PubMed=9657749; DOI=10.1182/blood.V92.2.496
Marc G. Jacquemin, Benoit G. Desqueper, Abdellah Benhida, Luc P. Vander Elst, Marc F. Hoylaerts, Marleen H.C. Bakkus, Kris Thielemans, Jef Arnout, Kathelijne Peerlinck, Jean-Guy G. Gilles, Jos Vermylen, Jean-Marie R. Saint-Remy;
Mechanism and kinetics of factor VIII inactivation: study with an IgG4 monoclonal antibody derived from a hemophilia A patient with inhibitor.
Blood 92:496-506(1998)

Cross-references
Encyclopedic resources Wikidata; Q54797916
Entry history
Entry creation22-Aug-2017
Last entry update29-Jun-2023
Version number6