| Cell line name |
NCI-H460 MX10 |
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| Synonyms |
H460 MX10 |
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| Accession |
CVCL_LB67 |
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| Resource Identification Initiative |
To cite this cell line use: NCI-H460 MX10 (RRID:CVCL_LB67) |
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| Comments |
Population: Caucasian.
Characteristics: Resistant to 10 nM of mitoxantrone (PubMed=11559526).
Selected for resistance to: ChEBI; CHEBI_50729; Mitoxantrone.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175. |
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| Sequence variations |
- Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gln61His (c.183A>T); ClinVar=VCV000045117; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11389; STK11; Simple; p.Gln37Ter (c.109C>T); ClinVar=VCV000376334; Zygosity=Homozygous (from parent cell line).
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| Disease |
Lung large cell carcinoma (NCIt: C4450) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_0459 (NCI-H460) |
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| Sex of cell |
Male |
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| Age at sampling |
Age unspecified |
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| Category |
Cancer cell line |
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| Publications | PubMed=11406094; DOI=10.1016/S0005-2736(01)00308-X
Robert W. Robey, Yasumasa Honjo, Anne van de Laar, Keisuke Miyake, Joanna T. Regis, Thomas Litman, Susan E. Bates;
A functional assay for detection of the mitoxantrone resistance protein, MXR (ABCG2).
Biochim. Biophys. Acta 1512:171-182(2001) PubMed=11559526
Yasumasa Honjo, Christine A. Hrycyna, Qing-Wu Yan, Wilma Y. Medina-Perez, Robert W. Robey, Anne van de Laar, Thomas Litman, Michael Dean, Susan E. Bates;
Acquired mutations in the MXR/BCRP/ABCP gene alter substrate specificity in MXR/BCRP/ABCP-overexpressing cells.
Cancer Res. 61:6635-6639(2001) PubMed=12642696; DOI=10.4161/cbt.322
Yasumasa Honjo, Kuniaki Morisaki, Lyn Mickley Huff, Robert W. Robey, Jeffrey Hung, Michael Dean, Susan E. Bates;
Single-nucleotide polymorphism (SNP) analysis in the ABC half-transporter ABCG2 (MXR/BCRP/ABCP1).
Cancer Biol. Ther. 1:696-702(2002) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_LB67
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| Encyclopedic resources |
Wikidata; Q54908058
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| Entry history |
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| Entry creation | 22-Aug-2017 |
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| Last entry update | 10-Apr-2025 |
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| Version number | 11 |
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