ID   NCI-H460 MX10
AC   CVCL_LB67
SY   H460 MX10
DR   cancercelllines; CVCL_LB67
DR   Wikidata; Q54908058
RX   PubMed=11406094;
RX   PubMed=11559526;
RX   PubMed=12642696;
CC   Population: Caucasian.
CC   Characteristics: Resistant to 10 nM of mitoxantrone (PubMed=11559526).
CC   Selected for resistance to: ChEBI; CHEBI_50729; Mitoxantrone.
CC   Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gln61His (c.183A>T); ClinVar=VCV000045117; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11389; STK11; Simple; p.Gln37Ter (c.109C>T); ClinVar=VCV000376334; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C4450; Lung large cell carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0459 ! NCI-H460
SX   Male
AG   Age unspecified
CA   Cancer cell line
DT   Created: 22-08-17; Last updated: 10-04-25; Version: 11
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RX   PubMed=11406094; DOI=10.1016/S0005-2736(01)00308-X;
RA   Robey R.W., Honjo Y., van de Laar A., Miyake K., Regis J.T.,
RA   Litman T., Bates S.E.;
RT   "A functional assay for detection of the mitoxantrone resistance
RT   protein, MXR (ABCG2).";
RL   Biochim. Biophys. Acta 1512:171-182(2001).
//
RX   PubMed=11559526;
RA   Honjo Y., Hrycyna C.A., Yan Q.-W., Medina-Perez W.Y., Robey R.W.,
RA   van de Laar A., Litman T., Dean M., Bates S.E.;
RT   "Acquired mutations in the MXR/BCRP/ABCP gene alter substrate
RT   specificity in MXR/BCRP/ABCP-overexpressing cells.";
RL   Cancer Res. 61:6635-6639(2001).
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RX   PubMed=12642696; DOI=10.4161/cbt.322;
RA   Honjo Y., Morisaki K., Huff L.M., Robey R.W., Hung J., Dean M.,
RA   Bates S.E.;
RT   "Single-nucleotide polymorphism (SNP) analysis in the ABC
RT   half-transporter ABCG2 (MXR/BCRP/ABCP1).";
RL   Cancer Biol. Ther. 1:696-702(2002).
//