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Cellosaurus Hep-G2/2.2.15 (CVCL_L855)

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Cell line name Hep-G2/2.2.15
Synonyms HEP-G2/2.2.15; Hep-G2/2215; HepG2/2215; HepG2-2.2.15; HepG2 2.2.15; HepG2.2.15; HepG2(2.2.15); 2.2.15
Accession CVCL_L855
Resource Identification Initiative To cite this cell line use: Hep-G2/2.2.15 (RRID:CVCL_L855)
Comments Population: Caucasian.
Virology: Contains 2 head to tails stably integrated hepatitis B virus (HBV) of the D-genotype.
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Hepatoblastoma (NCIt: C3728)
Hepatoblastoma (ORDO: Orphanet_449)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0027 (Hep-G2)
Sex of cell Male
Age at sampling 15Y
Category Cancer cell line
STR profile Source(s): Millipore=SCC249

Markers:
AmelogeninX,Y
CSF1PO10,11
D3S135815,16
D5S81811,12
D7S82010
D8S117915,16
D13S3179,13
D16S53912,13
D18S5113,14
D21S1129,31
FGA22,25
Penta D9,13
Penta E15,20
TH019
TPOX8,9
vWA17

Run an STR similarity search on this cell line
Publications

PubMed=3029758; DOI=10.1073/pnas.84.4.1005; PMCID=PMC304350
Mary Ann Sells, Mei-Ling Chen, George Acs;
Production of hepatitis B virus particles in Hep G2 cells transfected with cloned hepatitis B virus DNA.
Proc. Natl. Acad. Sci. U.S.A. 84:1005-1009(1987)

PubMed=8224613; DOI=10.1096/fasebj.7.14.8224613
Alain Puisieux, Katherine Galvin, Frederic Troalen, Brigitte Bressac, Christophe Marcais, Eithan Galun, Frederique Ponchel, Cengiz Yakicier, Jing-Wei Ji, Mehmet Ozturk;
Retinoblastoma and p53 tumor suppressor genes in human hepatoma cell lines.
FASEB J. 7:1407-1413(1993)

PubMed=21448419; DOI=10.3748/wjg.v17.i9.1152; PMCID=PMC3063907
Ran Zhao, Tian-Zhen Wang, Dan Kong, Lei Zhang, Hong-Xue Meng, Yang Jiang, Yi-Qi Wu, Zu-Xi Yu, Xiao-Ming Jin;
Hepatoma cell line HepG2.2.15 demonstrates distinct biological features compared with parental HepG2.
World J. Gastroenterol. 17:1152-1159(2011)

PubMed=29481805; DOI=10.1016/j.bbrc.2018.02.175
Naoki Ogura, Kazuya Ogawa, Koichi Watashi, Takayoshi Ito, Takaji Wakita;
Novel stable HBV producing cell line systems for expression and screening antiviral inhibitor of hepatitis B virus in human hepatoma cell line.
Biochem. Biophys. Res. Commun. 498:64-71(2018)

Cross-references
Cell line collections (Providers) CCTCC; GDC0141
Millipore; SCC249
Cell line databases/resources CLO; CLO_0001176
CLDB; cl33
cancercelllines; CVCL_L855
Anatomy/cell type resources BTO; BTO_0005621
Chemistry resources ChEMBL-Cells; CHEMBL3833241
ChEMBL-Targets; CHEMBL4296438
PubChem_Cell_line; CVCL_L855
Encyclopedic resources Wikidata; Q54882787
Polymorphism and mutation databases Cosmic; 979733
Entry history
Entry creation06-May-2013
Last entry update10-Apr-2025
Version number25